Palmitoyl-protein thioesterase 1 (P45479)

Uniprot ID P45479
Protein Name Palmitoyl-protein thioesterase 1
Gene Name Ppt1
Species Rattus norvegicus (Rat)
Signal peptide(a) Y Secretome P(b)
Function Removes thioester-linked fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides during lysosomal degradation. Prefers acyl chain lengths of 14 to 18 carbons. .
GO - Molecular function
  • lysophosphatidic acid binding : IEA:Ensembl
  • palmitoyl-(protein) hydrolase activity : ISS:UniProtKB
  • palmitoyl-CoA hydrolase activity : ISS:UniProtKB
  • sulfatide binding : ISS:UniProtKB
  • thiolester hydrolase activity : IBA:GO_Central
GO - Biological process
  • adult locomotory behavior : ISO:RGD
  • associative learning : ISO:RGD
  • brain development : ISS:UniProtKB
  • cellular macromolecule catabolic process : ISO:RGD
  • cellular protein catabolic process : ISO:RGD
  • cofactor metabolic process : ISS:UniProtKB
  • cofactor transport : ISS:UniProtKB
  • grooming behavior : ISO:RGD
  • lipid catabolic process : ISS:UniProtKB
  • lysosomal lumen acidification : ISS:UniProtKB
  • lysosome organization : ISO:RGD
  • membrane raft organization : ISS:UniProtKB
  • negative regulation of apoptotic process : ISS:UniProtKB
  • negative regulation of cell growth : ISS:UniProtKB
  • negative regulation of neuron apoptotic process : ISS:UniProtKB
  • nervous system development : ISS:UniProtKB
  • neurotransmitter secretion : ISO:RGD
  • pinocytosis : ISO:RGD
  • positive regulation of pinocytosis : ISS:UniProtKB
  • positive regulation of receptor-mediated endocytosis : ISS:UniProtKB
  • protein depalmitoylation : ISS:UniProtKB
  • protein transport : ISS:UniProtKB
  • receptor-mediated endocytosis : ISO:RGD
  • regulation of phospholipase A2 activity : ISO:RGD
  • regulation of synaptic plasticity : TAS:RGD
  • visual perception : ISO:RGD
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.