| Signal peptide(a) |
Y |
Secretome P(b) |
0.665 |
| Function |
Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. .Associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis. {ECO:0000269|PubMed:11114383}. |
| GO - Molecular function |
- cytokine activity : IEA:UniProtKB-KW
- cytokine receptor activity : IEA:InterPro
- growth factor activity : IEA:Ensembl
- identical protein binding : ISO:MGI
- interleukin-12 alpha subunit binding : IPI:MGI
- interleukin-23 receptor binding : IEA:Ensembl
- protein heterodimerization activity : ISO:MGI
- protein homodimerization activity : IDA:MGI
|
| GO - Biological process |
- cell cycle arrest : ISO:MGI
- cell migration : ISO:MGI
- cell proliferation : IDA:MGI
- cell surface receptor signaling pathway : IDA:MGI
- cellular response to interferon-gamma : IDA:MGI
- cellular response to lipopolysaccharide : IDA:MGI
- defense response to Gram-negative bacterium : ISO:MGI
- defense response to protozoan : IDA:MGI
- defense response to virus : IDA:MGI
- interferon-gamma production : IGI:MGI
- natural killer cell activation : ISS:UniProtKB
- natural killer cell activation involved in immune response : ISO:MGI
- negative regulation of growth of symbiont in host : IMP:MGI
- negative regulation of inflammatory response to antigenic stimulus : IMP:MGI
- negative regulation of interleukin-10 production : ISO:MGI
- negative regulation of interleukin-17 production : ISO:MGI
- negative regulation of smooth muscle cell proliferation : ISO:MGI
- positive regulation of activated T cell proliferation : ISS:UniProtKB
- positive regulation of activation of Janus kinase activity : ISO:MGI
- positive regulation of cell adhesion : ISO:MGI
- positive regulation of defense response to virus by host : IDA:BHF-UCL
- positive regulation of granulocyte macrophage colony-stimulating factor production : ISO:MGI
- positive regulation of interferon-gamma production : IDA:MGI
- positive regulation of interleukin-10 production : ISO:MGI
- positive regulation of interleukin-12 production : ISO:MGI
- positive regulation of interleukin-17 production : ISO:MGI
- positive regulation of lymphocyte proliferation : ISO:MGI
- positive regulation of mononuclear cell proliferation : ISO:MGI
- positive regulation of natural killer cell activation : ISO:MGI
- positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target : ISO:MGI
- positive regulation of natural killer cell proliferation : ISO:MGI
- positive regulation of NK T cell activation : ISO:MGI
- positive regulation of NK T cell proliferation : ISO:MGI
- positive regulation of osteoclast differentiation : ISO:MGI
- positive regulation of smooth muscle cell apoptotic process : ISO:MGI
- positive regulation of T cell mediated cytotoxicity : IDA:BHF-UCL
- positive regulation of T cell proliferation : IDA:MGI
- positive regulation of T-helper 1 type immune response : IDA:BHF-UCL
- positive regulation of tumor necrosis factor production : ISO:MGI
- positive regulation of tyrosine phosphorylation of STAT protein : ISO:MGI
- regulation of tyrosine phosphorylation of STAT protein : ISO:MGI
- response to organic substance : IDA:MGI
- response to UV-B : ISO:MGI
- sensory perception of pain : ISO:MGI
- T-helper 1 cell cytokine production : IGI:MGI
- T-helper cell differentiation : ISS:UniProtKB
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