| Signal peptide(a) |
N |
Secretome P(b) |
0.0 |
| Function |
Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart. Binds to ERBB4 and ERBB3. Acts as a ligand for integrins and binds (via EGF domain) to integrins ITGAV:ITGB3 or ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and ERRB3 are essential for NRG1-ERBB signaling (By similarity). Induces the phosphorylation and activation of MAPK3/ERK1, MAPK1/ERK2 and AKT1, and ligand-dependent ERBB4 endocytosis is essential for the NRG1-mediated activation of these kinases in neurons (PubMed:17250808). . |
| GO - Molecular function |
- chemorepellent activity : ISO:RGD
- ErbB-2 class receptor binding : ISO:RGD
- ErbB-3 class receptor binding : ISS:UniProtKB
- growth factor activity : ISO:RGD
- integrin binding : ISS:UniProtKB
- protein tyrosine kinase activator activity : ISO:RGD
- receptor tyrosine kinase binding : IDA:MGI
- signaling receptor binding : ISO:RGD
- transcription coregulator activity : ISO:RGD
|
| GO - Biological process |
- activation of MAPK activity : ISS:UniProtKB
- activation of protein kinase B activity : ISS:UniProtKB
- activation of transmembrane receptor protein tyrosine kinase activity : ISO:RGD
- animal organ development : IBA:GO_Central
- axon ensheathment : ISO:RGD
- brain development : ISO:RGD
- cardiac conduction system development : ISO:RGD
- cardiac muscle cell differentiation : ISO:RGD
- cardiac muscle cell myoblast differentiation : ISO:RGD
- cardiac muscle tissue development : ISO:RGD
- cell differentiation : IBA:GO_Central
- cell migration : ISO:RGD
- cell morphogenesis : ISO:RGD
- cell population proliferation : ISO:RGD
- cellular protein complex disassembly : ISO:RGD
- chemorepulsion involved in interneuron migration from the subpallium to the cortex : ISO:RGD
- endocardial cell differentiation : ISO:RGD
- ERBB signaling pathway : ISS:UniProtKB
- ERBB3 signaling pathway : ISO:RGD
- ERBB4 signaling pathway : ISO:RGD
- glial cell differentiation : ISO:RGD
- glial cell fate commitment : ISO:RGD
- heart development : ISO:RGD
- intracellular signal transduction : IBA:GO_Central
- locomotory behavior : ISO:RGD
- MAPK cascade : ISO:RGD
- memory : IMP:RGD
- muscle organ development : ISO:RGD
- myelination in peripheral nervous system : ISO:RGD
- negative regulation of cardiac muscle cell apoptotic process : ISO:RGD
- negative regulation of corticosterone secretion : IMP:RGD
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand : ISO:RGD
- negative regulation of neuron migration : ISO:RGD
- negative regulation of protein catabolic process : ISO:RGD
- negative regulation of secretion : ISO:RGD
- negative regulation of transcription, DNA-templated : ISO:RGD
- nervous system development : ISO:RGD
- neurogenesis : ISO:RGD
- neuron fate commitment : ISO:RGD
- neurotransmitter receptor metabolic process : ISO:RGD
- oligodendrocyte differentiation : ISO:RGD
- peripheral nervous system development : ISO:RGD
- positive regulation of axon extension : ISO:RGD
- positive regulation of axon regeneration : IDA:RGD
- positive regulation of calcineurin-NFAT signaling cascade : ISO:RGD
- positive regulation of cardiac muscle cell differentiation : ISO:RGD
- positive regulation of cardiac muscle cell proliferation : ISO:RGD
- positive regulation of cell adhesion : ISO:RGD
- positive regulation of cell growth : ISO:RGD
- positive regulation of cell population proliferation : IDA:RGD
- positive regulation of dendritic spine development : ISO:RGD
- positive regulation of gene expression : ISO:RGD
- positive regulation of myelination : ISO:RGD
- positive regulation of neuron projection development : IDA:RGD
- positive regulation of peptidyl-tyrosine autophosphorylation : ISO:RGD
- positive regulation of peptidyl-tyrosine phosphorylation : IDA:RGD
- positive regulation of phosphatidylinositol 3-kinase signaling : ISO:RGD
- positive regulation of protein kinase activity : ISO:RGD
- positive regulation of protein kinase B signaling : ISO:RGD
- positive regulation of protein localization to cell surface : ISO:RGD
- positive regulation of Ras protein signal transduction : ISO:RGD
- positive regulation of Schwann cell proliferation : IMP:RGD
- positive regulation of striated muscle cell differentiation : ISO:RGD
- positive regulation of transcription by RNA polymerase II : ISO:RGD
- postsynapse to nucleus signaling pathway : ISO:RGD
- regulation of cell differentiation : ISO:RGD
- regulation of postsynaptic neurotransmitter receptor internalization : ISO:RGD
- regulation of protein heterodimerization activity : ISO:RGD
- response to progesterone : IEP:RGD
- startle response : ISO:RGD
- synapse assembly : ISO:RGD
- synaptic membrane adhesion : ISO:RGD
- transmembrane receptor protein tyrosine kinase signaling pathway : ISO:RGD
- ventricular cardiac muscle cell differentiation : ISO:RGD
- ventricular trabecula myocardium morphogenesis : ISO:RGD
- wound healing : ISO:RGD
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