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P42930

Heat shock protein beta-1 (P42930)

Uniprot ID P42930
Protein Name Heat shock protein beta-1
Gene Name Hspb1
Species Rattus norvegicus (Rat)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) N Secretome P(b)
Function Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state. Plays a role in stress resistance and actin organization. Through its molecular chaperone activity may regulate numerous biological processes including the phosphorylation and the axonal transport of neurofilament proteins. .
GO - Molecular function
  • identical protein binding : ISS:UniProtKB
  • protein folding chaperone : ISS:UniProtKB
  • protein homodimerization activity : ISS:UniProtKB
  • protein kinase binding : ISO:RGD
  • protein kinase C binding : ISO:RGD
  • protein kinase C inhibitor activity : ISO:RGD
  • ubiquitin binding : IDA:RGD
GO - Biological process
  • aging : IEP:RGD
  • anterograde axonal protein transport : ISS:UniProtKB
  • cellular response to butyrate : IEP:RGD
  • cellular response to hydrogen peroxide : IEP:RGD
  • cellular response to interleukin-11 : IEP:RGD
  • cellular response to vascular endothelial growth factor stimulus : ISO:RGD
  • chaperone-mediated protein folding : ISS:UniProtKB
  • female pregnancy : IEP:RGD
  • intracellular signal transduction : ISO:RGD
  • negative regulation of apoptotic process : TAS:RGD
  • negative regulation of apoptotic signaling pathway : ISO:RGD
  • negative regulation of oxidative stress-induced cell death : IMP:RGD
  • negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway : ISO:RGD
  • negative regulation of protein kinase activity : ISO:RGD
  • positive regulation of angiogenesis : ISO:RGD
  • positive regulation of blood vessel endothelial cell migration : ISO:RGD
  • positive regulation of endothelial cell chemotaxis : ISO:RGD
  • positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway : ISO:RGD
  • positive regulation of interleukin-1 beta production : ISO:RGD
  • positive regulation of neuron projection development : IGI:ParkinsonsUK-UCL
  • positive regulation of tumor necrosis factor biosynthetic process : ISO:RGD
  • regulation of I-kappaB kinase/NF-kappaB signaling : ISO:RGD
  • regulation of protein phosphorylation : ISS:UniProtKB
  • response to angiotensin : IEP:RGD
  • response to ischemia : IEP:RGD
  • response to muscle stretch : IEP:RGD
  • response to virus : ISO:RGD
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.