| Signal peptide(a) |
N |
Secretome P(b) |
|
| Function |
Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely functions in the constitutive and regulated secretory pathways. Plays an essential role in pregnancy establishment by proteolytic activation of a number of important factors such as BMP2, CALD1 and alpha-integrins. May be responsible for the maturation of gastrointestinal peptides. May be involved in the cellular proliferation of adrenal cortex via the activation of growth factors. . |
| GO - Molecular function |
- endopeptidase activity : ISO:RGD
- peptidase activity : ISO:RGD
- peptide binding : ISO:RGD
- serine-type endopeptidase activity : ISO:RGD
|
| GO - Biological process |
- anterior/posterior pattern specification : ISO:RGD
- cardiac septum development : ISO:RGD
- cellular response to platelet-derived growth factor stimulus : IEP:RGD
- coronary vasculature development : ISO:RGD
- cytokine biosynthetic process : ISO:RGD
- determination of left/right symmetry : ISO:RGD
- embryo implantation : ISO:RGD
- embryonic digestive tract development : ISO:RGD
- embryonic skeletal system development : ISO:RGD
- heart development : ISO:RGD
- kidney development : ISO:RGD
- limb morphogenesis : ISO:RGD
- peptide biosynthetic process : ISO:RGD
- peptide hormone processing : ISO:RGD
- positive regulation of integrin activation : IMP:RGD
- positive regulation of integrin-mediated signaling pathway : IMP:RGD
- positive regulation of smooth muscle cell-matrix adhesion : IMP:RGD
- positive regulation of vascular associated smooth muscle cell migration : IMP:RGD
- protein processing : ISO:RGD
- renin secretion into blood stream : ISO:RGD
- respiratory tube development : ISO:RGD
- response to gonadotropin : IEP:RGD
- response to luteinizing hormone : IEP:RGD
- signal peptide processing : ISO:RGD
- vascular smooth muscle cell proliferation : IEP:RGD
- viral life cycle : ISO:RGD
|