Home Proteins Experiments Diseases Interactions Tutorial
Home
/
Proteins
/
P41274

Tumor necrosis factor ligand superfamily member 9 (P41274)

Uniprot ID P41274
Protein Name Tumor necrosis factor ligand superfamily member 9
Gene Name Tnfsf9
Species Mus musculus (Mouse)
Basic Information Experiments (1) Disease (2) Interactions
Signal peptide(a) N Secretome P(b) 0.872
Function Cytokine that binds to TNFRSF9. Induces the proliferation of activated peripheral blood T-cells. May have a role in activation-induced cell death (AICD). May play a role in cognate interactions between T-cells and B-cells/macrophages.
GO - Molecular function
  • cytokine activity : IEA:UniProtKB-KW
  • signaling receptor binding : IPI:MGI
  • tumor necrosis factor receptor binding : IEA:InterPro
  • tumor necrosis factor receptor superfamily binding : IPI:MGI
GO - Biological process
  • cell-cell signaling : IBA:GO_Central
  • immune response : IEA:InterPro
  • myeloid dendritic cell differentiation : ISO:MGI
  • positive regulation of activated T cell proliferation : ISO:MGI
  • positive regulation of cytotoxic T cell differentiation : ISO:MGI
  • positive regulation of interferon-gamma production : ISO:MGI
  • positive regulation of interleukin-12 production : ISO:MGI
  • positive regulation of interleukin-6 production : ISO:MGI
  • regulation of cell proliferation : IDA:MGI
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.