Signal transducer and activator of transcription 3 (P40763)

Uniprot ID	P40763
Protein Name	Signal transducer and activator of transcription 3
Gene Name	STAT3
Species	Homo sapiens (Human)

Signal peptide^(a)	N	Secretome P^(b)	0.609
Function	Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors (PubMed:10688651, PubMed:12359225, PubMed:12873986, PubMed:15194700, PubMed:17344214, PubMed:18242580, PubMed:23084476, PubMed:31462771). Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene (PubMed:17344214). May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4 (PubMed:12873986). Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes (PubMed:12359225). Activated by IL31 through IL31RA (PubMed:15194700). Acts as a regulator of inflammatory response by regulating differentiation of naive CD4(+) T-cells into T-helper Th17 or regulatory T-cells (Treg): deacetylation and oxidation of lysine residues by LOXL3, leads to disrupt STAT3 dimerization and inhibit its transcription activity (PubMed:28065600). Involved in cell cycle regulation by inducing the expression of key genes for the progression from G1 to S phase, such as CCND1 (PubMed:17344214). Mediates the effects of LEP on melanocortin production, body energy homeostasis and lactation (By similarity). May play an apoptotic role by transctivating BIRC5 expression under LEP activation (PubMed:18242580). Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity (PubMed:23084476). Plays a crucial role in basal beta cell functions, such as regulation of insulin secretion (By similarity). .
GO - Molecular function	CCR5 chemokine receptor binding : IEA:Ensembl chromatin DNA binding : IDA:UniProtKB DNA binding : ISS:UniProtKB DNA-binding transcription activator activity, RNA polymerase II-specific : IDA:BHF-UCL DNA-binding transcription factor activity : IDA:UniProtKB DNA-binding transcription factor activity, RNA polymerase II-specific : ISA:NTNU_SB glucocorticoid receptor binding : IEA:Ensembl identical protein binding : IPI:IntAct nuclear receptor activity : IDA:BHF-UCL protein dimerization activity : ISS:UniProtKB protein homodimerization activity : IDA:UniProtKB protein kinase binding : ISS:UniProtKB protein phosphatase binding : IPI:UniProtKB RNA polymerase II cis-regulatory region sequence-specific DNA binding : IDA:BHF-UCL RNA polymerase II repressing transcription factor binding : IPI:BHF-UCL transcription factor binding : IPI:UniProtKB transcription regulatory region DNA binding : IDA:BHF-UCL
GO - Biological process	acute-phase response : IEA:Ensembl aging : IEA:Ensembl astrocyte differentiation : ISS:UniProtKB cell population proliferation : IEA:Ensembl cellular response to cytokine stimulus : TAS:Reactome cellular response to hormone stimulus : IDA:BHF-UCL cellular response to leptin stimulus : IDA:UniProtKB cellular response to organic cyclic compound : IEA:Ensembl cytokine-mediated signaling pathway : IBA:GO_Central defense response : IBA:GO_Central eating behavior : ISS:UniProtKB energy homeostasis : ISS:UniProtKB eye photoreceptor cell differentiation : ISS:UniProtKB glucose homeostasis : ISS:UniProtKB growth hormone receptor signaling pathway : IDA:BHF-UCL growth hormone receptor signaling pathway via JAK-STAT : IDA:BHF-UCL inflammatory response : ISS:UniProtKB interleukin-15-mediated signaling pathway : TAS:Reactome interleukin-21-mediated signaling pathway : TAS:Reactome interleukin-23-mediated signaling pathway : TAS:Reactome interleukin-27-mediated signaling pathway : TAS:Reactome interleukin-35-mediated signaling pathway : TAS:Reactome interleukin-6-mediated signaling pathway : IDA:UniProtKB interleukin-7-mediated signaling pathway : TAS:Reactome interleukin-9-mediated signaling pathway : TAS:Reactome intracellular receptor signaling pathway : IDA:BHF-UCL leptin-mediated signaling pathway : IDA:UniProtKB miRNA mediated inhibition of translation : IDA:BHF-UCL modulation of chemical synaptic transmission : IEA:Ensembl mRNA transcription by RNA polymerase II : IEA:Ensembl negative regulation of autophagy : IDA:UniProtKB negative regulation of cell population proliferation : IEA:Ensembl negative regulation of glycolytic process : IEA:Ensembl negative regulation of hydrogen peroxide biosynthetic process : IEA:Ensembl negative regulation of neuron death : IEA:Ensembl negative regulation of neuron migration : IEA:Ensembl negative regulation of stem cell differentiation : IEA:Ensembl negative regulation of transcription by RNA polymerase II : TAS:ProtInc nervous system development : TAS:ProtInc phosphorylation : ISS:UniProtKB positive regulation of angiogenesis : IEA:Ensembl positive regulation of ATP biosynthetic process : IEA:Ensembl positive regulation of cell migration : IMP:ARUK-UCL positive regulation of erythrocyte differentiation : IMP:UniProtKB positive regulation of gene expression : IDA:BHF-UCL positive regulation of gene silencing by miRNA : IDA:BHF-UCL positive regulation of growth factor dependent skeletal muscle satellite cell proliferation : IEA:Ensembl positive regulation of interleukin-6 biosynthetic process : ISS:ARUK-UCL positive regulation of metalloendopeptidase activity : IGI:BHF-UCL positive regulation of NF-kappaB transcription factor activity : ISS:ARUK-UCL positive regulation of Notch signaling pathway : ISS:UniProtKB positive regulation of pri-miRNA transcription by RNA polymerase II : IDA:BHF-UCL positive regulation of transcription by RNA polymerase II : IDA:UniProtKB positive regulation of transcription, DNA-templated : IDA:BHF-UCL positive regulation of tyrosine phosphorylation of STAT protein : TAS:Reactome positive regulation of vascular endothelial cell proliferation : IEA:Ensembl postsynapse to nucleus signaling pathway : IEA:Ensembl protein import into nucleus : IDA:UniProtKB radial glial cell differentiation : ISS:UniProtKB receptor signaling pathway via JAK-STAT : IBA:GO_Central regulation of cell cycle : IDA:UniProtKB regulation of cell population proliferation : IBA:GO_Central regulation of feeding behavior : ISS:UniProtKB regulation of mitochondrial membrane permeability : IEA:Ensembl regulation of multicellular organism growth : IEA:Ensembl regulation of transcription by RNA polymerase II : ISS:UniProtKB regulation of transcription, DNA-templated : IDA:UniProtKB response to estradiol : IDA:BHF-UCL response to ethanol : IEA:Ensembl response to leptin : IDA:UniProtKB response to peptide hormone : IBA:GO_Central sexual reproduction : ISS:UniProtKB signal transduction : TAS:ProtInc somatic stem cell population maintenance : TAS:Reactome T-helper 17 cell lineage commitment : ISS:UniProtKB temperature homeostasis : ISS:UniProtKB viral process : IEA:UniProtKB-KW

Back

^{(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.}
^{(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.}