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P40753

Natriuretic peptides B (P40753)

Uniprot ID P40753
Protein Name Natriuretic peptides B
Gene Name Nppb
Species Mus musculus (Mouse)
Basic Information Experiments (1) Disease (5) Interactions
Signal peptide(a) Y Secretome P(b) 0.949
Function Cardiac hormone which may function as a paracrine antifibrotic factor in the heart. Also plays a key role in cardiovascular homeostasis through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3.
GO - Molecular function
  • hormone activity : ISO:MGI
  • peptide hormone receptor binding : ISO:MGI
GO - Biological process
  • cardiac muscle hypertrophy in response to stress : IDA:MGI
  • cGMP biosynthetic process : ISS:UniProtKB
  • negative regulation of cell growth : ISO:MGI
  • negative regulation of smooth muscle cell proliferation : ISO:MGI
  • negative regulation of systemic arterial blood pressure : ISO:MGI
  • positive regulation of collecting lymphatic vessel constriction : ISO:MGI
  • positive regulation of renal sodium excretion : ISO:MGI
  • positive regulation of urine volume : ISO:MGI
  • receptor guanylyl cyclase signaling pathway : ISS:UniProtKB
  • regulation of blood vessel size : IEA:UniProtKB-KW
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.