| Signal peptide(a) |
N |
Secretome P(b) |
0.191 |
| Function |
Transcription factor involved in the control of neuronal differentiation in the brain. Regulates dendrite development and branching, and dendritic spine formation in cortical layers II-III. Also involved in the control of synaptogenesis. In addition, it has probably a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr repressor; binds to the matrix attachment regions (MARs) (5' and 3') of the immunoglobulin heavy chain enhancer. Represses T-cell receptor (TCR) beta enhancer function by binding to MARbeta, an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Binds to the TH enhancer; may require the basic helix-loop-helix protein TCF4 as a coactivator. . |
| GO - Molecular function |
- protein binding, bridging : IEA:Ensembl
- RNA polymerase II regulatory region sequence-specific DNA binding : ISS:UniProtKB
- sequence-specific DNA binding : IDA:UniProtKB
|
| GO - Biological process |
- Golgi vesicle transport : IBA:GO_Central
- multicellular organism development : TAS:ProtInc
- negative regulation of transcription by RNA polymerase II : IBA:GO_Central
- positive regulation of dendrite morphogenesis : ISS:UniProtKB
- regulation of transcription by RNA polymerase II : TAS:ProtInc
- retrograde transport, vesicle recycling within Golgi : IEA:Ensembl
|