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P38983

40S ribosomal protein SA (P38983)

Uniprot ID P38983
Protein Name 40S ribosomal protein SA
Gene Name Rpsa
Species Rattus norvegicus (Rat)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) N Secretome P(b)
Function Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria. Acts as a PPP1R16B-dependent substrate of PPP1CA. .
GO - Molecular function
  • laminin binding : ISO:RGD
  • laminin receptor activity : TAS:RGD
  • ribosome binding : ISO:RGD
  • structural constituent of ribosome : IBA:GO_Central
  • structural molecule activity : IC:RGD
GO - Biological process
  • cell-cell adhesion : IDA:RGD
  • cytoplasmic translation : IBA:GO_Central
  • epithelial cell differentiation : IEP:RGD
  • ribosomal small subunit assembly : IBA:GO_Central
  • translation : IBA:GO_Central
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.