| Signal peptide(a) |
Y |
Secretome P(b) |
|
| Function |
Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at the synapse. |
| GO - Molecular function |
- apolipoprotein binding : IDA:RGD
- calcium ion binding : IBA:GO_Central
- carbohydrate binding : IEA:UniProtKB-KW
- ionotropic glutamate receptor binding : IDA:RGD
- unfolded protein binding : IEA:InterPro
|
| GO - Biological process |
- aging : IEP:RGD
- clathrin-dependent endocytosis : ISS:UniProtKB
- endoplasmic reticulum unfolded protein response : IBA:GO_Central
- protein folding : IBA:GO_Central
- synaptic vesicle endocytosis : ISS:UniProtKB
|