| Signal peptide(a) |
Y |
Secretome P(b) |
0.0 |
| Function |
Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Binds heparin. May play a role in dentinogenesis and/or maintenance of dentin and dental pulp. Ligand for CD36 mediating antiangiogenic properties (By similarity). Plays a role in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors. . |
| GO - Molecular function |
- calcium ion binding : IEA:InterPro
- collagen V binding : ISO:MGI
- extracellular matrix binding : IDA:MGI
- fibrinogen binding : ISO:MGI
- fibroblast growth factor binding : ISO:MGI
- fibronectin binding : ISO:MGI
- heparin binding : ISO:MGI
- integrin binding : ISO:MGI
- laminin binding : ISO:MGI
- low-density lipoprotein particle binding : ISO:MGI
- phosphatidylserine binding : ISO:MGI
- transforming growth factor beta binding : ISO:MGI
|
| GO - Biological process |
- activation of MAPK activity : ISO:MGI
- behavioral response to pain : IMP:UniProtKB
- blood vessel morphogenesis : IGI:MGI
- cell adhesion : IEA:UniProtKB-KW
- cell cycle arrest : ISO:MGI
- cell migration : ISO:MGI
- cellular response to nitric oxide : IMP:MGI
- endocardial cushion development : IGI:MGI
- engulfment of apoptotic cell : ISO:MGI
- extracellular matrix organization : IEA:InterPro
- growth plate cartilage development : IMP:MGI
- inflammatory response : IMP:MGI
- negative regulation of angiogenesis : IDA:MGI
- negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II : ISO:MGI
- negative regulation of apoptotic process : ISO:MGI
- negative regulation of blood vessel endothelial cell migration : ISO:MGI
- negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis : ISO:MGI
- negative regulation of cell migration involved in sprouting angiogenesis : ISO:MGI
- negative regulation of cell-matrix adhesion : ISO:MGI
- negative regulation of cGMP-mediated signaling : ISO:MGI
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process : ISO:MGI
- negative regulation of dendritic cell antigen processing and presentation : ISO:MGI
- negative regulation of endothelial cell chemotaxis : ISO:MGI
- negative regulation of endothelial cell migration : ISO:MGI
- negative regulation of endothelial cell proliferation : IMP:MGI
- negative regulation of fibrinolysis : ISO:MGI
- negative regulation of fibroblast growth factor receptor signaling pathway : ISO:MGI
- negative regulation of interleukin-12 production : ISO:MGI
- negative regulation of nitric oxide mediated signal transduction : ISO:MGI
- negative regulation of plasma membrane long-chain fatty acid transport : ISO:MGI
- negative regulation of plasminogen activation : ISO:MGI
- negative regulation of sprouting angiogenesis : ISO:MGI
- outflow tract morphogenesis : IGI:MGI
- peptide cross-linking : ISO:MGI
- positive regulation of angiogenesis : ISO:MGI
- positive regulation of blood coagulation : ISO:MGI
- positive regulation of blood vessel endothelial cell migration : ISO:MGI
- positive regulation of cell migration : ISO:MGI
- positive regulation of cell proliferation : ISO:MGI
- positive regulation of cell-substrate adhesion : IDA:MGI
- positive regulation of chemotaxis : ISO:MGI
- positive regulation of endothelial cell apoptotic process : ISO:MGI
- positive regulation of endothelial cell migration : ISO:MGI
- positive regulation of extrinsic apoptotic signaling pathway via death domain receptors : ISO:MGI
- positive regulation of fibroblast migration : ISO:MGI
- positive regulation of macrophage activation : ISO:MGI
- positive regulation of macrophage chemotaxis : IMP:BHF-UCL
- positive regulation of phosphorylation : ISO:MGI
- positive regulation of protein kinase B signaling : ISO:MGI
- positive regulation of reactive oxygen species metabolic process : ISO:MGI
- positive regulation of smooth muscle cell proliferation : ISO:MGI
- positive regulation of transforming growth factor beta production : ISO:MGI
- positive regulation of transforming growth factor beta receptor signaling pathway : IMP:BHF-UCL
- positive regulation of translation : ISO:MGI
- positive regulation of tumor necrosis factor biosynthetic process : ISO:MGI
- regulation of cGMP metabolic process : ISO:MGI
- response to calcium ion : ISO:MGI
- response to endoplasmic reticulum stress : IMP:UniProtKB
- response to glucose : ISO:MGI
- response to magnesium ion : ISO:MGI
- response to mechanical stimulus : ISO:MGI
- response to unfolded protein : IEA:UniProtKB-KW
- sprouting angiogenesis : ISO:MGI
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