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P35427

60S ribosomal protein L13a (P35427)

Uniprot ID P35427
Protein Name 60S ribosomal protein L13a
Gene Name Rpl13a
Species Rattus norvegicus (Rat)
Basic Information Experiments (1) Disease (2) Interactions
Signal peptide(a) N Secretome P(b)
Function Associated with ribosomes but is not required for canonical ribosome function and has extra-ribosomal functions Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation and subsequent phosphorylation dissociates from the ribosome and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation. In the GAIT complex interacts with m7G cap-bound eIF4G at or near the eIF3-binding site and blocks the recruitment of the 43S ribosomal complex (By similarity). .
GO - Molecular function
  • mRNA binding : ISO:RGD
  • structural constituent of ribosome : IBA:GO_Central
GO - Biological process
  • cellular response to cAMP : IEP:RGD
  • cellular response to gamma radiation : IEP:RGD
  • cellular response to interferon-gamma : ISO:RGD
  • cellular response to UV-B : IEP:RGD
  • homeostatic process : ISO:RGD
  • lung morphogenesis : ISO:RGD
  • macrophage chemotaxis : ISO:RGD
  • negative regulation of formation of translation preinitiation complex : ISS:UniProtKB
  • negative regulation of translation : ISS:UniProtKB
  • response to lipopolysaccharide : ISO:RGD
  • translation : IEA:InterPro
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.