ADM (P35318)

Uniprot ID	P35318
Protein Name	ADM
Gene Name	ADM
Species	Homo sapiens (Human)

Signal peptide^(a)	Y	Secretome P^(b)	0.701
Function	AM and PAMP are potent hypotensive and vasodilatator agents. Numerous actions have been reported most related to the physiologic control of fluid and electrolyte homeostasis. In the kidney, am is diuretic and natriuretic, and both am and pamp inhibit aldosterone secretion by direct adrenal actions. In pituitary gland, both peptides at physiologically relevant doses inhibit basal ACTH secretion. Both peptides appear to act in brain and pituitary gland to facilitate the loss of plasma volume, actions which complement their hypotensive effects in blood vessels.
GO - Molecular function	adrenomedullin receptor binding : IDA:UniProtKB hormone activity : IEA:UniProtKB-KW signaling receptor binding : TAS:ProtInc
GO - Biological process	adenylate cyclase-activating G protein-coupled receptor signaling pathway : IDA:UniProtKB adrenomedullin receptor signaling pathway : IDA:UniProtKB aging : IEA:Ensembl amylin receptor signaling pathway : IGI:ARUK-UCL androgen metabolic process : IEA:Ensembl animal organ regeneration : IEA:Ensembl antibacterial humoral response : IDA:UniProtKB antimicrobial humoral immune response mediated by antimicrobial peptide : IDA:UniProtKB branching involved in labyrinthine layer morphogenesis : IEA:Ensembl defense response to Gram-negative bacterium : IDA:UniProtKB defense response to Gram-positive bacterium : IDA:UniProtKB developmental growth : IEA:Ensembl female pregnancy : IEA:Ensembl G protein-coupled receptor internalization : IDA:UniProtKB G protein-coupled receptor signaling pathway : TAS:Reactome heart development : IEA:Ensembl hormone secretion : IEA:Ensembl inflammatory response : TAS:GO_Central negative regulation of cell population proliferation : IEA:Ensembl negative regulation of vascular permeability : IEA:Ensembl negative regulation of vasoconstriction : IDA:BHF-UCL neural tube closure : IEA:Ensembl neuron projection regeneration : IEA:Ensembl odontogenesis of dentin-containing tooth : IEA:Ensembl positive regulation of angiogenesis : IEA:Ensembl positive regulation of apoptotic process : IEA:Ensembl positive regulation of cell population proliferation : IEA:Ensembl positive regulation of cytosolic calcium ion concentration : IEA:Ensembl positive regulation of heart rate : IDA:UniProtKB positive regulation of progesterone biosynthetic process : TAS:GO_Central positive regulation of vasculogenesis : IEA:Ensembl receptor internalization : IDA:UniProtKB regulation of systemic arterial blood pressure : IDA:UniProtKB regulation of the force of heart contraction : IEA:Ensembl regulation of urine volume : IDA:UniProtKB response to cold : IEA:Ensembl response to glucocorticoid : IEA:Ensembl response to hypoxia : IEA:Ensembl response to insulin : IEA:Ensembl response to lipopolysaccharide : IEA:Ensembl response to starvation : IEA:Ensembl response to wounding : IEA:Ensembl signal transduction : TAS:ProtInc spongiotrophoblast layer development : IEA:Ensembl vascular smooth muscle cell development : IEA:Ensembl vasculogenesis : IDA:UniProtKB

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^{(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.}
^{(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.}