Catenin beta-1 (P35222)

Uniprot ID	P35222
Protein Name	Catenin beta-1
Gene Name	CTNNB1
Species	Homo sapiens (Human)

Signal peptide^(a)	N	Secretome P^(b)	0.705
Function	Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion, as component of an E-cadherin:catenin adhesion complex. Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2. Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22647378, PubMed:22699938, PubMed:22155184). Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle (By similarity). .
GO - Molecular function	alpha-catenin binding : IPI:BHF-UCL androgen receptor binding : NAS:UniProtKB cadherin binding : IPI:UniProtKB chromatin binding : ISS:ParkinsonsUK-UCL disordered domain specific binding : IEA:Ensembl DNA binding transcription factor activity : IEA:Ensembl enzyme binding : IPI:UniProtKB estrogen receptor binding : IPI:BHF-UCL I-SMAD binding : IPI:BHF-UCL ion channel binding : IPI:BHF-UCL kinase binding : IPI:BHF-UCL nuclear hormone receptor binding : IPI:BHF-UCL protein C-terminus binding : IPI:UniProtKB protein heterodimerization activity : IEA:Ensembl protein kinase binding : IEA:Ensembl protein phosphatase binding : IPI:UniProtKB repressing transcription factor binding : IEA:Ensembl RNA polymerase II activating transcription factor binding : IPI:BHF-UCL RNA polymerase II transcription coactivator activity : IDA:UniProtKB RNA polymerase II transcription factor binding : IDA:UniProtKB SMAD binding : IPI:BHF-UCL transcription coactivator activity : IDA:UniProtKB transcription factor binding : IPI:ParkinsonsUK-UCL
GO - Biological process	adherens junction assembly : IMP:BHF-UCL androgen receptor signaling pathway : NAS:UniProtKB anterior/posterior axis specification : IEA:Ensembl beta-catenin destruction complex disassembly : TAS:Reactome beta-catenin-TCF complex assembly : TAS:Reactome bone resorption : IEA:Ensembl branching involved in blood vessel morphogenesis : IC:BHF-UCL branching involved in ureteric bud morphogenesis : IEA:Ensembl canonical Wnt signaling pathway : IDA:UniProtKB canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation : IC:ParkinsonsUK-UCL canonical Wnt signaling pathway involved in negative regulation of apoptotic process : IMP:BHF-UCL canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation : ISS:BHF-UCL canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition : IMP:BHF-UCL cell adhesion : IMP:BHF-UCL cell fate specification : IEA:Ensembl cell maturation : IEA:Ensembl cell morphogenesis involved in differentiation : IEA:Ensembl cell-cell adhesion : IMP:BHF-UCL cell-matrix adhesion : IEA:Ensembl cellular response to growth factor stimulus : IMP:BHF-UCL cellular response to indole-3-methanol : IDA:UniProtKB central nervous system vasculogenesis : IEA:Ensembl chemical synaptic transmission : IEA:Ensembl chromatin-mediated maintenance of transcription : IEA:Ensembl cranial ganglion development : IEA:Ensembl cranial skeletal system development : IEA:Ensembl dorsal root ganglion development : IEA:Ensembl dorsal/ventral axis specification : IEA:Ensembl ectoderm development : IEA:Ensembl embryonic axis specification : IEA:Ensembl embryonic brain development : IEA:Ensembl embryonic digit morphogenesis : IEA:Ensembl embryonic foregut morphogenesis : IEA:Ensembl embryonic forelimb morphogenesis : IEA:Ensembl embryonic heart tube development : IEA:Ensembl embryonic hindlimb morphogenesis : IEA:Ensembl embryonic skeletal limb joint morphogenesis : ISS:BHF-UCL endodermal cell fate commitment : IEA:Ensembl endothelial tube morphogenesis : IMP:BHF-UCL entry of bacterium into host cell : TAS:Reactome epithelial cell differentiation involved in prostate gland development : IEA:Ensembl epithelial to mesenchymal transition : TAS:HGNC epithelial tube branching involved in lung morphogenesis : IEA:Ensembl fungiform papilla formation : IEA:Ensembl gastrulation with mouth forming second : IEA:Ensembl genitalia morphogenesis : IEA:Ensembl glial cell fate determination : IEA:Ensembl hair cell differentiation : TAS:BHF-UCL hair follicle morphogenesis : IEA:Ensembl hair follicle placode formation : IEA:Ensembl hindbrain development : IEA:Ensembl in utero embryonic development : IEA:Ensembl layer formation in cerebral cortex : IEA:Ensembl lens morphogenesis in camera-type eye : IEA:Ensembl lung cell differentiation : IEA:Ensembl lung induction : IEA:Ensembl lung-associated mesenchyme development : IEA:Ensembl male genitalia development : IEA:Ensembl mesenchymal cell proliferation involved in lung development : IEA:Ensembl metanephros morphogenesis : IEA:Ensembl midbrain dopaminergic neuron differentiation : ISS:ParkinsonsUK-UCL negative regulation of angiogenesis : ISS:BHF-UCL negative regulation of apoptotic signaling pathway : IEA:Ensembl negative regulation of cell death : TAS:ARUK-UCL negative regulation of cell proliferation : IDA:UniProtKB negative regulation of chondrocyte differentiation : IEA:Ensembl negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis : IEA:Ensembl negative regulation of mitotic cell cycle, embryonic : ISS:UniProtKB negative regulation of oligodendrocyte differentiation : IEA:Ensembl negative regulation of osteoclast differentiation : IEA:Ensembl negative regulation of oxidative stress-induced neuron death : IEA:Ensembl negative regulation of protein sumoylation : IDA:UniProtKB negative regulation of transcription by RNA polymerase II : IEA:Ensembl negative regulation of transcription, DNA-templated : IMP:UniProtKB nephron tubule formation : IEA:Ensembl neural plate development : IEA:Ensembl neuron migration : IEA:Ensembl neuron projection extension : IMP:UniProtKB odontogenesis of dentin-containing tooth : IEA:Ensembl oocyte development : IEA:Ensembl osteoclast differentiation : IEA:Ensembl oviduct development : IEA:Ensembl pancreas development : IEA:Ensembl positive regulation of apoptotic process : IDA:UniProtKB positive regulation of chromatin-mediated maintenance of transcription : IEA:Ensembl positive regulation of core promoter binding : IDA:BHF-UCL positive regulation of determination of dorsal identity : IEA:Ensembl positive regulation of DNA binding transcription factor activity : IMP:ParkinsonsUK-UCL positive regulation of DNA-templated transcription, initiation : IC:BHF-UCL positive regulation of endothelial cell differentiation : IEA:Ensembl positive regulation of epithelial cell proliferation involved in prostate gland development : IEA:Ensembl positive regulation of epithelial to mesenchymal transition : IGI:MGI positive regulation of fibroblast growth factor receptor signaling pathway : IEA:Ensembl positive regulation of heparan sulfate proteoglycan biosynthetic process : IMP:BHF-UCL positive regulation of histone H3-K4 methylation : IC:BHF-UCL positive regulation of I-kappaB kinase/NF-kappaB signaling : IEA:Ensembl positive regulation of MAPK cascade : IEA:Ensembl positive regulation of mesenchymal cell proliferation : IEA:Ensembl positive regulation of muscle cell differentiation : TAS:Reactome positive regulation of neuroblast proliferation : ISS:UniProtKB positive regulation of neuron apoptotic process : IDA:ParkinsonsUK-UCL positive regulation of osteoblast differentiation : IEA:Ensembl positive regulation of skeletal muscle tissue development : IEA:Ensembl positive regulation of telomerase activity : IEA:Ensembl positive regulation of telomere maintenance via telomerase : IEA:Ensembl positive regulation of transcription by RNA polymerase II : IDA:UniProtKB positive regulation of transcription, DNA-templated : IDA:UniProtKB positive regulation of type I interferon production : TAS:Reactome protein localization to cell surface : IMP:BHF-UCL proximal/distal pattern formation : IEA:Ensembl regulation of angiogenesis : TAS:BHF-UCL regulation of calcium ion import : IDA:BHF-UCL regulation of centriole-centriole cohesion : IDA:UniProtKB regulation of centromeric sister chromatid cohesion : IMP:BHF-UCL regulation of euchromatin binding : IEA:Ensembl regulation of fibroblast proliferation : TAS:BHF-UCL regulation of myelination : IEA:Ensembl regulation of nephron tubule epithelial cell differentiation : ISS:UniProtKB regulation of neurogenesis : TAS:ParkinsonsUK-UCL regulation of protein localization to cell surface : IDA:BHF-UCL regulation of secondary heart field cardioblast proliferation : IEA:Ensembl regulation of smooth muscle cell proliferation : IMP:BHF-UCL regulation of T cell proliferation : IEA:Ensembl regulation of timing of anagen : IEA:Ensembl renal inner medulla development : IEA:Ensembl renal outer medulla development : IEA:Ensembl renal vesicle formation : IEA:Ensembl response to drug : IEP:UniProtKB response to estradiol : IDA:BHF-UCL smooth muscle cell differentiation : IEA:Ensembl stem cell population maintenance : TAS:BHF-UCL sympathetic ganglion development : ISS:UniProtKB synapse organization : IEA:Ensembl synaptic vesicle transport : IEA:Ensembl T cell differentiation in thymus : IEA:Ensembl thymus development : IEA:Ensembl trachea formation : IEA:Ensembl Wnt signaling pathway : TAS:Reactome Wnt signaling pathway, calcium modulating pathway : TAS:Reactome

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^{(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.}
^{(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.}