| Signal peptide(a) |
N |
Secretome P(b) |
|
| Function |
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2. Negative regulator of signaling cascades that mediate activation of MAP kinases via AKAP13. . |
| GO - Molecular function |
- enzyme binding : ISO:RGD
- histone deacetylase binding : ISO:RGD
- identical protein binding : ISO:RGD
- phosphoprotein binding : ISO:RGD
- phosphoserine residue binding : ISO:RGD
- protein C-terminus binding : IPI:RGD
- protein domain specific binding : ISO:RGD
- protein-containing complex binding : IPI:RGD
|
| GO - Biological process |
- cytoplasmic sequestering of protein : ISO:RGD
- negative regulation of G protein-coupled receptor signaling pathway : ISS:UniProtKB
- negative regulation of protein dephosphorylation : ISO:RGD
- negative regulation of transcription, DNA-templated : IMP:RGD
- positive regulation of catalytic activity : ISO:RGD
- protein targeting : ISO:RGD
|