| Signal peptide(a) |
Y |
Secretome P(b) |
0.287 |
| Function |
Growth factor that binds to EGFR, ERBB4 and other EGF receptor family members. Potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells. . |
| GO - Molecular function |
- epidermal growth factor receptor binding : IBA:GO_Central
- growth factor activity : IBA:GO_Central
- phosphatidylinositol-4,5-bisphosphate 3-kinase activity : TAS:Reactome
- protein tyrosine kinase activity : TAS:Reactome
- Ras guanyl-nucleotide exchange factor activity : TAS:Reactome
|
| GO - Biological process |
- epidermal growth factor receptor signaling pathway : IBA:GO_Central
- ERBB2 signaling pathway : TAS:Reactome
- MAPK cascade : TAS:Reactome
- negative regulation of apoptotic process : IEA:Ensembl
- positive regulation of cell differentiation : IEA:Ensembl
- positive regulation of cell division : IEA:UniProtKB-KW
- positive regulation of cell proliferation : TAS:ProtInc
- positive regulation of fibroblast proliferation : IEA:Ensembl
- positive regulation of mitotic nuclear division : IEA:Ensembl
- positive regulation of protein kinase B signaling : TAS:Reactome
- positive regulation of urine volume : IEA:Ensembl
- regulation of cell motility : TAS:Reactome
|