72 kDa type IV collagenase (P33436)

Uniprot ID	P33436
Protein Name	72 kDa type IV collagenase
Gene Name	Mmp2
Species	Rattus norvegicus (Rat)

Signal peptide^(a)	Y	Secretome P^(b)
Function	Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-\|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro. Involved in the formation of the fibrovascular tissues (By similarity). .PEX, the C-terminal non-catalytic fragment of MMP2, posseses anti-angiogenic and anti-tumor properties and inhibits cell migration and cell adhesion to FGF2 and vitronectin. Ligand for integrin alpha-v/beta3 on the surface of blood vessels (By similarity). {ECO:0000250}.
GO - Molecular function	fibronectin binding : IPI:RGD metalloendopeptidase activity : ISO:RGD metallopeptidase activity : ISO:RGD peptidase activity : IDA:RGD serine-type endopeptidase activity : ISO:RGD zinc ion binding : IEA:InterPro
GO - Biological process	aging : IDA:RGD angiogenesis : IEP:RGD blood vessel maturation : ISO:RGD bone trabecula formation : ISO:RGD cell migration : IMP:RGD cellular response to amino acid stimulus : ISO:RGD cellular response to cytokine stimulus : IEP:RGD cellular response to estradiol stimulus : IMP:RGD cellular response to fluid shear stress : IEP:RGD cellular response to interleukin-1 : IEP:RGD cellular response to reactive oxygen species : ISO:RGD collagen catabolic process : IDA:RGD embryo implantation : ISO:RGD endodermal cell differentiation : ISO:RGD extracellular matrix organization : IBA:GO_Central face morphogenesis : ISO:RGD female pregnancy : IEP:RGD heart development : IDA:RGD intramembranous ossification : ISO:RGD luteinization : IEP:RGD negative regulation of cell adhesion : IDA:RGD negative regulation of vasoconstriction : IDA:RGD ovarian follicle development : IDA:RGD ovulation from ovarian follicle : IEP:RGD parturition : IEP:RGD peripheral nervous system axon regeneration : IDA:RGD positive regulation of apoptotic process : IDA:RGD positive regulation of cell migration : IMP:RGD positive regulation of innate immune response : ISO:RGD positive regulation of smooth muscle cell proliferation : ISO:RGD positive regulation of vascular smooth muscle cell proliferation : ISO:RGD prostate gland epithelium morphogenesis : IMP:RGD proteolysis : IDA:RGD response to activity : IEP:RGD response to amyloid-beta : ISO:RGD response to cytokine : IEP:RGD response to drug : IDA:RGD response to electrical stimulus : IEP:RGD response to estrogen : IDA:RGD response to hydrogen peroxide : IDA:RGD response to hyperoxia : IEP:RGD response to hypoxia : IDA:RGD response to mechanical stimulus : IDA:RGD response to nicotine : IEP:RGD response to oxidative stress : IDA:RGD response to radiation : IEP:RGD response to retinoic acid : IEP:RGD skeletal system morphogenesis : ISO:RGD tissue remodeling : IDA:RGD

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^{(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.}
^{(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.}