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P32921

Tryptophan--tRNA ligase, cytoplasmic (P32921)

Uniprot ID P32921
Protein Name Tryptophan--tRNA ligase, cytoplasmic
Gene Name Wars
Species Mus musculus (Mouse)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.556
Function T1-TrpRS has aminoacylation activity while T2-TrpRS lacks it. T1-TrpRS and T2-TrpRS possess angiostatic activity. T2-TrpRS inhibits fluid shear stress-activated responses of endothelial cells. Regulates ERK, Akt, and eNOS activation pathways that are associated with angiogenesis, cytoskeletal reorganization and shear stress-responsive gene expression (By similarity). .
GO - Molecular function
  • ATP binding : IEA:UniProtKB-KW
  • kinase inhibitor activity : ISO:MGI
  • protein domain specific binding : ISO:MGI
  • protein homodimerization activity : ISS:UniProtKB
  • protein kinase binding : ISO:MGI
  • tryptophan-tRNA ligase activity : IMP:CAFA
GO - Biological process
  • angiogenesis : IEA:UniProtKB-KW
  • negative regulation of protein kinase activity : ISO:MGI
  • negative regulation of protein phosphorylation : ISO:MGI
  • positive regulation of gene expression : ISO:MGI
  • positive regulation of protein complex assembly : ISO:MGI
  • regulation of angiogenesis : ISO:MGI
  • regulation of protein ADP-ribosylation : ISO:MGI
  • tryptophanyl-tRNA aminoacylation : IDA:CAFA
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.