Nectin-2 (P32507)

Uniprot ID P32507
Protein Name Nectin-2
Gene Name Nectin2
Species Mus musculus (Mouse)
Signal peptide(a) Y Secretome P(b) 0.14
Function Modulator of T-cell signaling. Can be either a costimulator of T-cell function, or a coinhibitor, depending on the receptor it binds to. Upon binding to CD226, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Upon interaction with PVRIG, inhibits T-cell proliferation. These interactions are competitive. Probable cell adhesion protein. .
GO - Molecular function
  • cell adhesion molecule binding : IPI:BHF-UCL
  • identical protein binding : IPI:IntAct
  • protein homodimerization activity : IDA:HGNC
  • signaling receptor binding : IBA:GO_Central
GO - Biological process
  • acrosome assembly : IMP:MGI
  • adhesion of symbiont to host : ISO:MGI
  • cell part morphogenesis : IMP:MGI
  • cell recognition : IBA:GO_Central
  • cilium organization : IMP:MGI
  • coreceptor-mediated virion attachment to host cell : ISO:MGI
  • cytoskeleton organization : IMP:MGI
  • establishment of mitochondrion localization : IMP:MGI
  • fertilization : IMP:MGI
  • fusion of virus membrane with host plasma membrane : ISO:MGI
  • heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules : IBA:GO_Central
  • homophilic cell adhesion via plasma membrane adhesion molecules : IDA:HGNC
  • positive regulation of immunoglobulin mediated immune response : ISO:MGI
  • positive regulation of mast cell activation : ISO:MGI
  • positive regulation of natural killer cell mediated cytotoxicity : ISO:MGI
  • positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target : ISO:MGI
  • positive regulation of T cell receptor signaling pathway : ISO:MGI
  • regulation of viral entry into host cell : ISO:MGI
  • sperm mitochondrion organization : IMP:MGI
  • spermatid development : IMP:BHF-UCL
  • spermatid nucleus differentiation : IMP:MGI
  • susceptibility to natural killer cell mediated cytotoxicity : ISO:MGI
  • susceptibility to T cell mediated cytotoxicity : ISO:MGI
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.