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P32261

Antithrombin-III (P32261)

Uniprot ID P32261
Protein Name Antithrombin-III
Gene Name Serpinc1
Species Mus musculus (Mouse)
Basic Information Experiments (2) Disease (0) Interactions
Signal peptide(a) Y Secretome P(b) 0.611
Function Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin (By similarity). .
GO - Molecular function
  • heparin binding : ISO:MGI
  • identical protein binding : ISO:MGI
  • protease binding : ISO:MGI
  • serine-type endopeptidase inhibitor activity : ISO:MGI
GO - Biological process
  • acute inflammatory response to antigenic stimulus : IEA:Ensembl
  • blood coagulation : IEA:UniProtKB-KW
  • lactation : IEA:Ensembl
  • regulation of blood coagulation, intrinsic pathway : IEA:InterPro
  • response to nutrient : ISO:MGI
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.