Neural cell adhesion molecule L1 (P32004)

Uniprot ID P32004
Protein Name Neural cell adhesion molecule L1
Gene Name L1CAM
Species Homo sapiens (Human)
Signal peptide(a) N Secretome P(b) 0.386
Function Neural cell adhesion molecule involved in the dynamics of cell adhesion and in the generation of transmembrane signals at tyrosine kinase receptors. During brain development, critical in multiple processes, including neuronal migration, axonal growth and fasciculation, and synaptogenesis. In the mature brain, plays a role in the dynamics of neuronal structure and function, including synaptic plasticity. .
GO - Molecular function
  • axon guidance receptor activity : IBA:GO_Central
  • protein domain specific binding : IDA:CAFA
GO - Biological process
  • axon development : IDA:UniProtKB
  • axon guidance : IDA:UniProtKB
  • cell adhesion : NAS:ProtInc
  • cell migration : IDA:UniProtKB
  • cell-matrix adhesion : IDA:UniProtKB
  • chemotaxis : TAS:BHF-UCL
  • homophilic cell adhesion via plasma membrane adhesion molecules : IBA:GO_Central
  • leukocyte migration : TAS:Reactome
  • nervous system development : TAS:ProtInc
  • neuron projection development : IDA:UniProtKB
  • positive regulation of axon extension : ISS:UniProtKB
  • synapse organization : IDA:UniProtKB
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.