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P31939

Bifunctional purine biosynthesis protein PURH (P31939)

Uniprot ID P31939
Protein Name Bifunctional purine biosynthesis protein PURH
Gene Name ATIC
Species Homo sapiens (Human)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.617
Function Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis. .Promotes insulin receptor/INSR autophosphorylation and is involved in INSR internalization (PubMed:25687571). {ECO:0000269|PubMed:25687571}.
GO - Molecular function
  • cadherin binding : HDA:BHF-UCL
  • IMP cyclohydrolase activity : TAS:Reactome
  • phosphoribosylaminoimidazolecarboxamide formyltransferase activity : TAS:Reactome
  • protein homodimerization activity : IPI:UniProtKB
GO - Biological process
  • 'de novo' IMP biosynthetic process : IEA:UniProtKB-UniPathway
  • animal organ regeneration : IEA:Ensembl
  • brainstem development : IEA:Ensembl
  • cerebellum development : IEA:Ensembl
  • cerebral cortex development : IEA:Ensembl
  • dihydrofolate metabolic process : IEA:Ensembl
  • nucleobase-containing compound metabolic process : TAS:ProtInc
  • nucleoside metabolic process : IEA:Ensembl
  • purine ribonucleoside monophosphate biosynthetic process : TAS:Reactome
  • response to inorganic substance : IEA:Ensembl
  • tetrahydrofolate biosynthetic process : IEA:Ensembl
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.