Fibroblast growth factor 9 (P31371)

Uniprot ID	P31371
Protein Name	Fibroblast growth factor 9
Gene Name	FGF9
Species	Homo sapiens (Human)

Signal peptide^(a)	N	Secretome P^(b)	0.915
Function	Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. May have a role in glial cell growth and differentiation during development, gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation of glial tumors. .
GO - Molecular function	fibroblast growth factor receptor binding : IEA:Ensembl growth factor activity : TAS:ProtInc heparin binding : IEA:UniProtKB-KW
GO - Biological process	angiogenesis : IEA:Ensembl cell-cell signaling : TAS:ProtInc chondrocyte differentiation : IEA:Ensembl embryonic digestive tract development : IEA:Ensembl embryonic limb morphogenesis : IEA:Ensembl embryonic skeletal system development : IEA:Ensembl eye development : IEA:Ensembl fibroblast growth factor receptor signaling pathway : IGI:MGI inner ear morphogenesis : IEA:Ensembl lung-associated mesenchyme development : IEA:Ensembl male gonad development : IEP:UniProtKB male sex determination : IEA:Ensembl MAPK cascade : TAS:Reactome negative regulation of transcription by RNA polymerase II : IEA:Ensembl negative regulation of vascular smooth muscle cell differentiation involved in phenotypic switching : ISS:BHF-UCL negative regulation of Wnt signaling pathway : IEA:Ensembl osteoblast differentiation : IEA:Ensembl positive regulation of activin receptor signaling pathway : IEA:Ensembl positive regulation of canonical Wnt signaling pathway : IEA:Ensembl positive regulation of cardiac muscle cell proliferation : IEA:Ensembl positive regulation of cell division : IEA:UniProtKB-KW positive regulation of cell population proliferation : IDA:MGI positive regulation of epithelial cell proliferation : IEA:Ensembl positive regulation of gene expression : IEA:Ensembl positive regulation of MAPK cascade : IEA:Ensembl positive regulation of mesenchymal cell proliferation : IEA:Ensembl positive regulation of protein kinase B signaling : TAS:Reactome positive regulation of smoothened signaling pathway : IEA:Ensembl positive regulation of vascular associated smooth muscle cell migration : ISS:BHF-UCL positive regulation of vascular endothelial growth factor receptor signaling pathway : IEA:Ensembl positive regulation of vascular smooth muscle cell proliferation : IGI:BHF-UCL protein import into nucleus : IEA:Ensembl regulation of timing of cell differentiation : IEA:Ensembl signal transduction : TAS:ProtInc substantia nigra development : HEP:UniProtKB

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^{(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.}
^{(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.}