| Signal peptide(a) |
N |
Secretome P(b) |
|
| Function |
Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity (By similarity). . |
| GO - Molecular function |
- chemoattractant activity : ISO:RGD
- cytokine activity : ISO:RGD
- cytokine receptor binding : ISO:RGD
- dopachrome isomerase activity : ISS:UniProtKB
- identical protein binding : ISO:RGD
- phenylpyruvate tautomerase activity : ISO:RGD
- protease binding : ISO:RGD
- protein-containing complex binding : IDA:RGD
- signaling receptor binding : ISO:RGD
|
| GO - Biological process |
- aging : IEP:RGD
- brain development : IEP:RGD
- brain renin-angiotensin system : IMP:RGD
- carboxylic acid metabolic process : ISO:RGD
- cell aging : ISO:RGD
- cell population proliferation : ISO:RGD
- cell surface receptor signaling pathway : ISO:RGD
- cellular response to hydrogen peroxide : IEP:RGD
- cellular response to hypoxia : IEP:RGD
- DNA damage response, signal transduction by p53 class mediator : ISO:RGD
- drinking behavior : IMP:RGD
- hair follicle development : IEP:RGD
- inflammatory response : IEA:UniProtKB-KW
- innate immune response : IEA:UniProtKB-KW
- negative regulation of apoptotic process : ISO:RGD
- negative regulation of cell aging : ISO:RGD
- negative regulation of cell cycle arrest : ISO:RGD
- negative regulation of cell migration : ISO:RGD
- negative regulation of cellular protein metabolic process : ISO:RGD
- negative regulation of DNA damage response, signal transduction by p53 class mediator : ISO:RGD
- negative regulation of gene expression : ISO:RGD
- negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator : ISO:RGD
- negative regulation of macrophage chemotaxis : ISO:RGD
- negative regulation of mature B cell apoptotic process : ISO:RGD
- negative regulation of myeloid cell apoptotic process : ISO:RGD
- positive regulation of acute inflammatory response : IMP:RGD
- positive regulation of arachidonic acid secretion : ISO:RGD
- positive regulation of axon regeneration : IMP:RGD
- positive regulation of B cell proliferation : ISO:RGD
- positive regulation of chemokine (C-X-C motif) ligand 2 production : ISO:RGD
- positive regulation of cytokine secretion : ISO:RGD
- positive regulation of ERK1 and ERK2 cascade : ISO:RGD
- positive regulation of fibroblast proliferation : ISO:RGD
- positive regulation of glucose import : IMP:RGD
- positive regulation of glycolytic process : IMP:RGD
- positive regulation of immune response : IMP:RGD
- positive regulation of lipopolysaccharide-mediated signaling pathway : ISO:RGD
- positive regulation of MAP kinase activity : ISO:RGD
- positive regulation of myeloid leukocyte cytokine production involved in immune response : ISO:RGD
- positive regulation of peptidyl-serine phosphorylation : ISO:RGD
- positive regulation of peptidyl-tyrosine phosphorylation : ISO:RGD
- positive regulation of phosphorylation : ISO:RGD
- positive regulation of potassium ion transport : IMP:RGD
- positive regulation of prostaglandin secretion involved in immune response : ISO:RGD
- positive regulation of protein kinase A signaling : ISO:RGD
- positive regulation of protein phosphorylation : ISO:RGD
- positive regulation of smooth muscle cell migration : IMP:RGD
- positive regulation of tumor necrosis factor production : ISO:RGD
- prostaglandin biosynthetic process : ISO:RGD
- protein homotrimerization : ISO:RGD
- regulation of cell population proliferation : ISO:RGD
- response to drug : IEP:RGD
- response to estradiol : IEP:RGD
- response to glucocorticoid : IEP:RGD
- response to heat : IEP:RGD
- response to hormone : IEP:RGD
- response to inorganic substance : IEP:RGD
- response to insulin : IEP:RGD
- response to lipopolysaccharide : IEP:RGD
- response to mechanical stimulus : IEP:RGD
- response to menaquinone : IEP:RGD
- response to progesterone : IEP:RGD
- response to vitamin E : IEP:RGD
- skin development : IEP:RGD
- spermatogenesis : IMP:RGD
- wound healing : IEP:RGD
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