| Signal peptide(a) |
N |
Secretome P(b) |
0.309 |
| Function |
Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. In the nucleus is an abundant chromatin-associated non-histone protein involved in transcription, chromatin remodeling and V(D)J recombination and probably other processes. Binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters by enhancing transcription factor binding and/or bringing distant regulatory sequences into close proximity (By similarity). Involved in V(D)J recombination by acting as a cofactor of the RAG complex: acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS) (PubMed:9184213). Proposed to be involved in the innate immune response to nucleic acids by acting as a cytoplasmic promiscuous immunogenic DNA/RNA sensor which cooperates with subsequent discriminative sensing by specific pattern recognition receptors (PubMed:19890330). In the extracellular compartment acts as a chemokine. Promotes proliferation and migration of endothelial cells implicating AGER/RAGE (By similarity). Has antimicrobial activity in gastrointestinal epithelial tissues (By similarity). Involved in inflammatory response to antigenic stimulus coupled with proinflammatory activity (PubMed:25306442). May play a role in germ cell differentiation (PubMed:11262228). Involved in modulation of neurogenesis probably by regulation of neural stem proliferation (PubMed:24391977). Involved in articular cartilage surface maintenance implicating LEF1 and the Wnt/beta-catenin pathway (PubMed:19805379). . |
| GO - Molecular function |
- chemoattractant activity : ISO:MGI
- damaged DNA binding : ISO:MGI
- DNA binding : ISS:AgBase
- DNA binding transcription factor activity : ISO:MGI
- DNA binding, bending : ISS:UniProtKB
- double-stranded DNA binding : IDA:UniProtKB
- enhancer sequence-specific DNA binding : IDA:AgBase
- non-sequence-specific DNA binding, bending : ISS:AgBase
- protein domain specific binding : IPI:MGI
- RAGE receptor binding : ISO:MGI
- supercoiled DNA binding : ISS:AgBase
- transcription factor binding : IDA:AgBase
- transcription regulatory region DNA binding : ISO:MGI
|
| GO - Biological process |
- cell chemotaxis : ISO:MGI
- cellular response to lipopolysaccharide : IEA:Ensembl
- defense response to Gram-negative bacterium : ISS:AgBase
- defense response to Gram-positive bacterium : ISS:AgBase
- DNA recombination : IEA:UniProtKB-KW
- DNA topological change : ISS:AgBase
- inflammatory response to antigenic stimulus : IMP:AgBase
- innate immune response : IEA:UniProtKB-KW
- male gonad development : IMP:MGI
- negative regulation of extrinsic apoptotic signaling pathway via death domain receptors : IMP:MGI
- negative regulation of gene expression : IDA:AgBase
- negative regulation of transcription, DNA-templated : ISO:MGI
- positive regulation of DNA binding : IDA:MGI
- positive regulation of endothelial cell proliferation : ISO:MGI
- positive regulation of erythrocyte differentiation : ISO:MGI
- positive regulation of gene expression : IDA:AgBase
- positive regulation of innate immune response : IMP:UniProtKB
- positive regulation of interferon-beta production : IMP:UniProtKB
- positive regulation of megakaryocyte differentiation : ISO:MGI
- positive regulation of nuclease activity : ISO:MGI
- positive regulation of transcription by RNA polymerase II : IMP:MGI
- positive regulation of transcription, DNA-templated : ISO:MGI
- regulation of neurogenesis : IMP:AgBase
- regulation of stem cell proliferation : IMP:AgBase
- regulation of transcription by RNA polymerase II : IDA:MGI
- response to lipopolysaccharide : IMP:AgBase
- response to steroid hormone : IMP:MGI
- spermatid nucleus differentiation : IMP:MGI
- spermatogenesis : IMP:MGI
- transcription, DNA-templated : IEA:UniProtKB-KW
|