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P30427

Plectin (P30427)

Uniprot ID P30427
Protein Name Plectin
Gene Name Plec
Species Rattus norvegicus (Rat)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) N Secretome P(b)
Function Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. May be involved not only in the cross-linking and stabilization of cytoskeletal intermediate filaments network, but also in the regulation of their dynamics.
GO - Molecular function
  • actin binding : IEA:UniProtKB-KW
  • ankyrin binding : IPI:BHF-UCL
  • cytoskeletal protein binding : IDA:RGD
  • protein N-terminus binding : IDA:RGD
  • structural constituent of cytoskeleton : IMP:RGD
  • structural constituent of muscle : ISO:RGD
  • structural molecule activity : IBA:GO_Central
GO - Biological process
  • epithelial cell differentiation : IEP:RGD
  • female pregnancy : IEP:RGD
  • hemidesmosome assembly : ISS:UniProtKB
  • intermediate filament cytoskeleton organization : IBA:GO_Central
  • response to nutrient : IDA:RGD
  • wound healing : IBA:GO_Central
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.