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P30348

C-X-C motif chemokine 2 (P30348)

Uniprot ID P30348
Protein Name C-X-C motif chemokine 2
Gene Name Cxcl2
Species Rattus norvegicus (Rat)
Basic Information Experiments (3) Disease (9) Interactions
Signal peptide(a) Y Secretome P(b)
Function Chemotactic for human polymorphonuclear leukocytes but does not induce chemokinesis or an oxidative burst. Contributes to neutrophil activation during inflammation.
GO - Molecular function
  • chemokine activity : IDA:RGD
  • CXCR chemokine receptor binding : IBA:GO_Central
GO - Biological process
  • antimicrobial humoral immune response mediated by antimicrobial peptide : ISO:RGD
  • cellular response to interleukin-1 : IEP:RGD
  • cellular response to lipopolysaccharide : IEP:RGD
  • chemokine-mediated signaling pathway : IBA:GO_Central
  • immune response : IBA:GO_Central
  • inflammatory response : IBA:GO_Central
  • killing of cells of other organism : ISO:RGD
  • leukocyte chemotaxis : IMP:RGD
  • neuron death : IDA:RGD
  • neutrophil chemotaxis : IMP:RGD
  • positive regulation of cytosolic calcium ion concentration : IDA:RGD
  • response to amphetamine : IEP:RGD
  • response to estradiol : IEP:RGD
  • response to gamma radiation : IEP:RGD
  • response to glucocorticoid : IEP:RGD
  • response to heat : IEP:RGD
  • response to molecule of bacterial origin : ISO:RGD
  • wound healing : IEP:RGD
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.