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P30204

Macrophage scavenger receptor types I and II (P30204)

Uniprot ID P30204
Protein Name Macrophage scavenger receptor types I and II
Gene Name Msr1
Species Mus musculus (Mouse)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.0
Function Membrane glycoproteins implicated in the pathologic deposition of cholesterol in arterial walls during atherogenesis. Two types of receptor subunits exist. These receptors mediate the endocytosis of a diverse group of macromolecules, including modified low density lipoproteins (LDL). .
GO - Molecular function
  • amyloid-beta binding : IGI:ARUK-UCL
  • cargo receptor activity : IGI:ARUK-UCL
  • low-density lipoprotein particle binding : IMP:BHF-UCL
  • scavenger receptor activity : IEA:InterPro
GO - Biological process
  • amyloid-beta clearance : IMP:ARUK-UCL
  • cholesterol transport : IMP:BHF-UCL
  • lipoprotein transport : IMP:MGI
  • negative regulation of gene expression : IMP:ARUK-UCL
  • phagocytosis, engulfment : IGI:ARUK-UCL
  • plasma lipoprotein particle clearance : IMP:BHF-UCL
  • positive regulation of cholesterol storage : IMP:BHF-UCL
  • positive regulation of macrophage derived foam cell differentiation : IGI:BHF-UCL
  • receptor-mediated endocytosis : IGI:ARUK-UCL
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.