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P30009

Myristoylated alanine-rich C-kinase substrate (P30009)

Uniprot ID P30009
Protein Name Myristoylated alanine-rich C-kinase substrate
Gene Name Marcks
Species Rattus norvegicus (Rat)
Basic Information Experiments (2) Disease (0) Interactions
Signal peptide(a) N Secretome P(b)
Function MARCKS is the most prominent cellular substrate for protein kinase C. This protein binds calmodulin, actin, and synapsin. MARCKS is a filamentous (F) actin cross-linking protein.
GO - Molecular function
  • actin filament binding : ISO:RGD
  • calmodulin binding : ISO:RGD
  • identical protein binding : ISO:RGD
  • phosphatidylserine binding : IDA:RGD
  • phospholipid binding : IDA:RGD
  • protein kinase C binding : ISO:RGD
GO - Biological process
  • actin crosslink formation : ISO:RGD
  • actin filament bundle assembly : ISO:RGD
  • actin filament organization : IMP:RGD
  • activation of phospholipase D activity : IDA:RGD
  • brain development : IEP:RGD
  • cell-substrate adhesion : IDA:RGD
  • intracellular protein transport : IMP:RGD
  • positive regulation of dendritic spine morphogenesis : IMP:RGD
  • positive regulation of insulin receptor signaling pathway : IMP:RGD
  • positive regulation of neuron projection development : IMP:RGD
  • positive regulation of protein kinase C activity : IDA:RGD
  • protein homooligomerization : ISO:RGD
  • regulation of modification of postsynaptic actin cytoskeleton : IDA:SynGO
  • ventricular cardiac muscle tissue development : IEP:RGD
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.