Serpin H1 (P29457)

Uniprot ID P29457
Protein Name Serpin H1
Gene Name Serpinh1
Species Rattus norvegicus (Rat)
Signal peptide(a) Y Secretome P(b)
Function Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen.
GO - Molecular function
  • collagen binding : TAS:RGD
  • serine-type endopeptidase inhibitor activity : IBA:GO_Central
  • unfolded protein binding : ISO:RGD
GO - Biological process
  • chondrocyte development involved in endochondral bone morphogenesis : ISO:RGD
  • collagen biosynthetic process : ISO:RGD
  • collagen fibril organization : ISO:RGD
  • negative regulation of endopeptidase activity : IBA:GO_Central
  • protein maturation : ISO:RGD
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.