| Signal peptide(a) |
Y |
Secretome P(b) |
0.841 |
| Function |
Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes (By similarity). Mediates heparin-and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells (By similarity). Enhances fibroblast growth factor-induced DNA synthesis (By similarity). . |
| GO - Molecular function |
- fibronectin binding : ISO:MGI
- growth factor activity : ISO:MGI
- heparin binding : IDA:MGI
- insulin-like growth factor binding : IEA:InterPro
- integrin binding : IDA:MGI
- protein C-terminus binding : ISO:MGI
|
| GO - Biological process |
- aging : IEA:Ensembl
- angiogenesis : IDA:MGI
- cartilage condensation : IDA:MGI
- cell differentiation : IDA:MGI
- cell migration : IDA:MGI
- cell-cell signaling : IBA:GO_Central
- cell-matrix adhesion : IDA:MGI
- chondrocyte proliferation : IMP:MGI
- connective tissue development : IMP:MGI
- cytosolic calcium ion transport : ISO:MGI
- DNA biosynthetic process : IEA:UniProtKB-KW
- extracellular matrix constituent secretion : ISO:MGI
- fibroblast growth factor receptor signaling pathway : IDA:MGI
- integrin-mediated signaling pathway : IDA:MGI
- intracellular signal transduction : ISO:MGI
- lung development : IMP:MGI
- negative regulation of cell death : ISO:MGI
- negative regulation of gene expression : IMP:MGI
- ossification : IMP:MGI
- positive regulation of cardiac muscle contraction : ISO:MGI
- positive regulation of cell activation : ISO:MGI
- positive regulation of cell death : ISO:MGI
- positive regulation of cell differentiation : ISO:MGI
- positive regulation of cell proliferation : ISO:MGI
- positive regulation of collagen biosynthetic process : ISO:MGI
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process : ISO:MGI
- positive regulation of ERK1 and ERK2 cascade : ISO:MGI
- positive regulation of G0 to G1 transition : ISO:MGI
- positive regulation of gene expression : ISO:MGI
- positive regulation of JNK cascade : ISO:MGI
- positive regulation of protein phosphorylation : ISO:MGI
- positive regulation of stress fiber assembly : ISO:MGI
- reactive oxygen species metabolic process : IDA:MGI
- regulation of cell growth : IEA:InterPro
- regulation of chondrocyte differentiation : IMP:MGI
- response to amino acid : IEA:Ensembl
- response to anoxia : IEA:Ensembl
- response to estradiol : IEA:Ensembl
- response to fatty acid : IEA:Ensembl
- response to glucose : IEA:Ensembl
- response to mineralocorticoid : IEA:Ensembl
- response to peptide hormone : IEA:Ensembl
- tissue homeostasis : IMP:MGI
|