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P28862

Stromelysin-1 (P28862)

Uniprot ID P28862
Protein Name Stromelysin-1
Gene Name Mmp3
Species Mus musculus (Mouse)
Basic Information Experiments (4) Disease (0) Interactions
Signal peptide(a) Y Secretome P(b) 0.0
Function Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase.
GO - Molecular function
  • endopeptidase activity : ISO:MGI
  • metalloendopeptidase activity : TAS:Reactome
  • metallopeptidase activity : ISO:MGI
  • protein-containing complex binding : ISO:MGI
  • serine-type endopeptidase activity : TAS:Reactome
  • zinc ion binding : IEA:InterPro
GO - Biological process
  • cellular response to amino acid stimulus : IDA:MGI
  • collagen catabolic process : IEA:UniProtKB-KW
  • negative regulation of hydrogen peroxide metabolic process : ISO:MGI
  • negative regulation of protein kinase B signaling : IMP:ParkinsonsUK-UCL
  • positive regulation of cell migration : ISO:MGI
  • positive regulation of oxidative stress-induced cell death : IMP:ParkinsonsUK-UCL
  • positive regulation of protein oligomerization : ISO:MGI
  • protein catabolic process : IMP:ParkinsonsUK-UCL
  • proteolysis : IMP:ParkinsonsUK-UCL
  • regulation of cell migration : IMP:MGI
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.