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P28828

Receptor-type tyrosine-protein phosphatase mu (P28828)

Uniprot ID P28828
Protein Name Receptor-type tyrosine-protein phosphatase mu
Gene Name Ptprm
Species Mus musculus (Mouse)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) Y Secretome P(b) 0.244
Function Involved in cell-cell adhesion through homophilic interactions. May play a key role in signal transduction and growth control.
GO - Molecular function
  • cadherin binding : ISS:UniProtKB
  • identical protein binding : ISO:MGI
  • protein tyrosine phosphatase activity : ISO:MGI
  • transmembrane receptor protein tyrosine phosphatase activity : ISS:UniProtKB
GO - Biological process
  • homophilic cell adhesion via plasma membrane adhesion molecules : ISS:UniProtKB
  • negative regulation of angiogenesis : ISS:UniProtKB
  • negative regulation of endothelial cell migration : ISS:UniProtKB
  • negative regulation of endothelial cell proliferation : ISS:UniProtKB
  • neuron projection development : ISS:UniProtKB
  • positive regulation of blood vessel diameter : IMP:MGI
  • protein dephosphorylation : ISS:UniProtKB
  • response to drug : ISS:UniProtKB
  • retina layer formation : ISS:UniProtKB
  • retinal ganglion cell axon guidance : ISS:UniProtKB
  • signal transduction : ISS:UniProtKB
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.