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P28827

Receptor-type tyrosine-protein phosphatase mu (P28827)

Uniprot ID P28827
Protein Name Receptor-type tyrosine-protein phosphatase mu
Gene Name PTPRM
Species Homo sapiens (Human)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) Y Secretome P(b) 0.241
Function Involved in cell-cell adhesion through homophilic interactions. May play a key role in signal transduction and growth control. .
GO - Molecular function
  • cadherin binding : IDA:UniProtKB
  • identical protein binding : IPI:IntAct
  • protein tyrosine phosphatase activity : IDA:UniProtKB
  • transmembrane receptor protein tyrosine phosphatase activity : IDA:UniProtKB
GO - Biological process
  • homophilic cell adhesion via plasma membrane adhesion molecules : IDA:UniProtKB
  • negative regulation of angiogenesis : IMP:UniProtKB
  • negative regulation of endothelial cell migration : IMP:UniProtKB
  • negative regulation of endothelial cell proliferation : IMP:UniProtKB
  • neuron projection development : IDA:UniProtKB
  • positive regulation of blood vessel diameter : IEA:Ensembl
  • protein dephosphorylation : IDA:UniProtKB
  • response to drug : IDA:UniProtKB
  • retina layer formation : IMP:UniProtKB
  • retinal ganglion cell axon guidance : IDA:UniProtKB
  • signal transduction : IDA:UniProtKB
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.