Decorin (P28654)

Uniprot ID P28654
Protein Name Decorin
Gene Name Dcn
Species Mus musculus (Mouse)
Signal peptide(a) Y Secretome P(b) 0.595
Function May affect the rate of fibrils formation.
GO - Molecular function
  • collagen binding : ISO:MGI
  • extracellular matrix binding : IDA:MGI
  • glycosaminoglycan binding : IDA:MGI
  • protein kinase inhibitor activity : IBA:GO_Central
  • protein N-terminus binding : ISO:MGI
GO - Biological process
  • aging : IEA:Ensembl
  • cytokine-mediated signaling pathway : IBA:GO_Central
  • kidney development : IEA:Ensembl
  • negative regulation of angiogenesis : ISO:MGI
  • negative regulation of endothelial cell migration : ISO:MGI
  • negative regulation of JAK-STAT cascade : IBA:GO_Central
  • negative regulation of protein kinase activity : IBA:GO_Central
  • negative regulation of vascular endothelial growth factor signaling pathway : ISO:MGI
  • peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan : IDA:MGI
  • placenta development : IEA:Ensembl
  • positive regulation of autophagy : ISO:MGI
  • positive regulation of macroautophagy : ISO:MGI
  • positive regulation of mitochondrial depolarization : ISO:MGI
  • positive regulation of mitochondrial fission : ISO:MGI
  • positive regulation of phosphatidylinositol 3-kinase signaling : ISO:MGI
  • positive regulation of transcription by RNA polymerase II : ISO:MGI
  • response to lipopolysaccharide : IEA:Ensembl
  • response to mechanical stimulus : IEA:Ensembl
  • skeletal muscle tissue development : IEA:Ensembl
  • wound healing : IEA:Ensembl
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.