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P28650

Adenylosuccinate synthetase isozyme 1 (P28650)

Uniprot ID P28650
Protein Name Adenylosuccinate synthetase isozyme 1
Gene Name Adssl1
Species Mus musculus (Mouse)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.572
Function Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. .
GO - Molecular function
  • actin filament binding : ISO:MGI
  • adenylosuccinate synthase activity : IDA:MGI
  • GTP binding : IEA:UniProtKB-KW
  • GTPase activity : ISO:MGI
  • metal ion binding : IEA:UniProtKB-KW
  • protein homodimerization activity : ISO:MGI
GO - Biological process
  • 'de novo' AMP biosynthetic process : IBA:GO_Central
  • AMP biosynthetic process : ISO:MGI
  • aspartate metabolic process : ISO:MGI
  • cellular response to drug : IEA:Ensembl
  • cellular response to electrical stimulus : IEA:Ensembl
  • glutamine metabolic process : IEA:Ensembl
  • IMP metabolic process : ISO:MGI
  • purine nucleotide metabolic process : IDA:MGI
  • purine ribonucleoside monophosphate biosynthetic process : ISO:MGI
  • response to muscle activity : IEA:Ensembl
  • response to starvation : IEA:Ensembl
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.