Platelet-derived growth factor subunit A (P28576)

Uniprot ID	P28576
Protein Name	Platelet-derived growth factor subunit A
Gene Name	Pdgfa
Species	Rattus norvegicus (Rat)

Signal peptide^(a)	N	Secretome P^(b)	0.786
Function	Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal lung alveolar septum formation during embryogenesis, normal development of the gastrointestinal tract, normal development of Leydig cells and spermatogenesis. Required for normal oligodendrocyte development and normal myelination in the spinal cord and cerebellum. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFB (By similarity). .
GO - Molecular function	collagen binding : ISS:UniProtKB growth factor activity : ISS:UniProtKB identical protein binding : ISO:RGD platelet-derived growth factor binding : ISO:RGD platelet-derived growth factor receptor binding : ISS:UniProtKB protein heterodimerization activity : ISO:RGD protein homodimerization activity : ISS:UniProtKB
GO - Biological process	actin cytoskeleton organization : ISS:UniProtKB angiogenesis : ISS:UniProtKB animal organ morphogenesis : ISS:UniProtKB bone development : ISO:RGD cell projection assembly : ISS:UniProtKB cellular response to transforming growth factor beta stimulus : IEP:RGD digestive tract development : ISO:RGD embryonic lung development : ISO:RGD hair follicle development : ISS:UniProtKB inner ear development : IEP:RGD lung alveolus development : ISS:UniProtKB male gonad development : IEP:RGD negative chemotaxis : ISS:UniProtKB negative regulation of phosphatidylinositol biosynthetic process : ISS:UniProtKB negative regulation of platelet activation : ISS:UniProtKB platelet-derived growth factor receptor signaling pathway : ISS:UniProtKB positive regulation of cell division : IEA:UniProtKB-KW positive regulation of cell migration : ISS:UniProtKB positive regulation of cell population proliferation : IMP:RGD positive regulation of ERK1 and ERK2 cascade : ISS:UniProtKB positive regulation of fibroblast proliferation : ISS:UniProtKB positive regulation of MAP kinase activity : ISS:UniProtKB positive regulation of MAPK cascade : ISS:UniProtKB positive regulation of mesenchymal cell proliferation : ISS:UniProtKB positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway : ISS:UniProtKB positive regulation of phosphatidylinositol 3-kinase signaling : ISS:UniProtKB positive regulation of protein autophosphorylation : ISS:UniProtKB positive regulation of protein kinase B signaling : ISS:UniProtKB regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling : ISS:UniProtKB regulation of peptidyl-tyrosine phosphorylation : ISS:UniProtKB regulation of smooth muscle cell migration : ISS:UniProtKB response to drug : IEP:RGD response to estradiol : IEP:RGD response to hypoxia : IEP:RGD response to inorganic substance : IEP:RGD response to organic substance : IEP:RGD response to retinoic acid : IEP:RGD response to wounding : ISS:UniProtKB skin development : ISS:UniProtKB wound healing : IEP:RGD

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^{(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.}
^{(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.}