Collagen alpha-1(II) chain (P28481)

Uniprot ID P28481
Protein Name Collagen alpha-1(II) chain
Gene Name Col2a1
Species Mus musculus (Mouse)
Signal peptide(a) Y Secretome P(b) 0.123
Function Type II collagen is specific for cartilaginous tissues. It is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces.
GO - Molecular function
  • extracellular matrix structural constituent : IEA:InterPro
  • identical protein binding : IPI:IntAct
  • metal ion binding : IEA:UniProtKB-KW
  • MHC class II protein binding : ISO:MGI
  • platelet-derived growth factor binding : ISO:MGI
GO - Biological process
  • anterior head development : IMP:MGI
  • bone development : IMP:MGI
  • cartilage condensation : IMP:MGI
  • cartilage development : IMP:MGI
  • cartilage development involved in endochondral bone morphogenesis : IMP:MGI
  • cellular response to BMP stimulus : IDA:MGI
  • central nervous system development : IEP:UniProtKB
  • chondrocyte differentiation : IMP:MGI
  • collagen fibril organization : IMP:MGI
  • embryonic skeletal joint morphogenesis : ISO:MGI
  • endochondral ossification : IMP:MGI
  • heart morphogenesis : IMP:MGI
  • inner ear development : IMP:MGI
  • inner ear morphogenesis : IMP:MGI
  • limb bud formation : IEP:UniProtKB
  • limb morphogenesis : IMP:MGI
  • negative regulation of extrinsic apoptotic signaling pathway in absence of ligand : IMP:MGI
  • notochord development : IEP:UniProtKB
  • ossification : IEP:UniProtKB
  • otic vesicle development : IEP:UniProtKB
  • proteoglycan metabolic process : IMP:MGI
  • regulation of gene expression : IMP:MGI
  • roof of mouth development : IMP:MGI
  • sensory perception of sound : ISO:MGI
  • skeletal system development : ISO:MGI
  • skeletal system morphogenesis : IMP:MGI
  • tissue homeostasis : IMP:MGI
  • visual perception : ISO:MGI
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.