Proteasome subunit beta type-5 (P28074)

Uniprot ID	P28074
Protein Name	Proteasome subunit beta type-5
Gene Name	PSMB5
Species	Homo sapiens (Human)

Signal peptide^(a)	N	Secretome P^(b)	0.88
Function	Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB5 displays a chymotrypsin-like activity. .
GO - Molecular function	endopeptidase activity : IBA:GO_Central peptidase activity : IDA:MGI threonine-type endopeptidase activity : IEA:UniProtKB-KW
GO - Biological process	anaphase-promoting complex-dependent catabolic process : TAS:Reactome antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent : TAS:Reactome Fc-epsilon receptor signaling pathway : TAS:Reactome interleukin-1-mediated signaling pathway : TAS:Reactome MAPK cascade : TAS:Reactome negative regulation of canonical Wnt signaling pathway : TAS:Reactome negative regulation of G2/M transition of mitotic cell cycle : TAS:Reactome NIK/NF-kappaB signaling : TAS:Reactome positive regulation of canonical Wnt signaling pathway : TAS:Reactome post-translational protein modification : TAS:Reactome proteasomal protein catabolic process : IBA:GO_Central proteasomal ubiquitin-independent protein catabolic process : IBA:GO_Central proteasome-mediated ubiquitin-dependent protein catabolic process : IBA:GO_Central protein deubiquitination : TAS:Reactome protein polyubiquitination : TAS:Reactome proteolysis : IDA:MGI regulation of cellular amino acid metabolic process : TAS:Reactome regulation of hematopoietic stem cell differentiation : TAS:Reactome regulation of mitotic cell cycle phase transition : TAS:Reactome regulation of mRNA stability : TAS:Reactome regulation of transcription from RNA polymerase II promoter in response to hypoxia : TAS:Reactome response to oxidative stress : IEA:Ensembl SCF-dependent proteasomal ubiquitin-dependent protein catabolic process : TAS:Reactome stimulatory C-type lectin receptor signaling pathway : TAS:Reactome T cell receptor signaling pathway : TAS:Reactome transmembrane transport : TAS:Reactome tumor necrosis factor-mediated signaling pathway : TAS:Reactome viral process : IEA:UniProtKB-KW Wnt signaling pathway, planar cell polarity pathway : TAS:Reactome

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^{(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.}
^{(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.}