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P28063

Proteasome subunit beta type-8 (P28063)

Uniprot ID P28063
Protein Name Proteasome subunit beta type-8
Gene Name Psmb8
Species Mus musculus (Mouse)
Basic Information Experiments (2) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.684
Function The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. May be involved in the inflammatory response pathway. Required for adipocyte differentiation. .
GO - Molecular function
  • threonine-type endopeptidase activity : IEA:UniProtKB-KW
GO - Biological process
  • antigen processing and presentation : IMP:MGI
  • fat cell differentiation : IMP:UniProtKB
  • proteolysis involved in cellular protein catabolic process : IEA:InterPro
  • regulation of endopeptidase activity : ISO:MGI
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.