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P27658

Collagen alpha-1(VIII) chain (P27658)

Uniprot ID P27658
Protein Name Collagen alpha-1(VIII) chain
Gene Name COL8A1
Species Homo sapiens (Human)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) Y Secretome P(b) 0.402
Function Macromolecular component of the subendothelium. Major component of the Descemet's membrane (basement membrane) of corneal endothelial cells. Also component of the endothelia of blood vessels. Necessary for migration and proliferation of vascular smooth muscle cells and thus, has a potential role in the maintenance of vessel wall integrity and structure, in particular in atherogenesis. .Vastatin, the C-terminal fragment comprising the NC1 domain, inhibits aortic endothelial cell proliferation and causes cell apoptosis. {ECO:0000269|PubMed:11708810}.
GO - Molecular function
GO - Biological process
  • angiogenesis : IEA:UniProtKB-KW
  • camera-type eye morphogenesis : IEA:Ensembl
  • cell adhesion : IEA:UniProtKB-KW
  • endodermal cell differentiation : IEP:UniProtKB
  • epithelial cell proliferation : IEA:Ensembl
  • extracellular matrix organization : TAS:Reactome
  • positive regulation of cell-substrate adhesion : IEA:Ensembl
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.