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P27046

Alpha-mannosidase 2 (P27046)

Uniprot ID P27046
Protein Name Alpha-mannosidase 2
Gene Name Man2a1
Species Mus musculus (Mouse)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.579
Function Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway. .
GO - Molecular function
  • alpha-mannosidase activity : IBA:GO_Central
  • carbohydrate binding : IEA:InterPro
  • hydrolase activity : IDA:MGI
  • hydrolase activity, hydrolyzing N-glycosyl compounds : IDA:MGI
  • mannosidase activity : IDA:MGI
  • mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity : IEA:UniProtKB-EC
  • metal ion binding : IEA:UniProtKB-KW
GO - Biological process
  • in utero embryonic development : IGI:MGI
  • liver development : IGI:MGI
  • lung alveolus development : IGI:MGI
  • mannose metabolic process : IBA:GO_Central
  • mitochondrion organization : IGI:MGI
  • N-glycan processing : IGI:MGI
  • positive regulation of neurogenesis : IMP:MGI
  • protein deglycosylation : IBA:GO_Central
  • protein glycosylation : IEA:UniProtKB-UniPathway
  • respiratory gaseous exchange : IGI:MGI
  • retina morphogenesis in camera-type eye : IMP:MGI
  • vacuole organization : IGI:MGI
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.