| Signal peptide(a) |
N |
Secretome P(b) |
0.783 |
| Function |
Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruits SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). . |
| GO - Molecular function |
- activin binding : ISO:MGI
- drug binding : IDA:MGI
- enzyme binding : ISO:MGI
- FK506 binding : IDA:MGI
- Hsp70 protein binding : ISO:MGI
- ion channel binding : IPI:BHF-UCL
- peptidyl-prolyl cis-trans isomerase activity : ISO:MGI
- protein homodimerization activity : IDA:MGI
- SMAD binding : ISO:MGI
- transforming growth factor beta receptor binding : ISO:MGI
- type I transforming growth factor beta receptor binding : ISO:MGI
|
| GO - Biological process |
- amyloid fibril formation : ISO:MGI
- chaperone-mediated protein folding : IBA:GO_Central
- cytokine-mediated signaling pathway : IMP:MGI
- heart morphogenesis : IMP:BHF-UCL
- heart trabecula formation : IMP:BHF-UCL
- muscle contraction : IMP:MGI
- negative regulation of phosphoprotein phosphatase activity : ISO:MGI
- negative regulation of protein phosphorylation : IDA:MGI
- positive regulation of protein binding : ISO:MGI
- positive regulation of protein ubiquitination : ISO:MGI
- protein peptidyl-prolyl isomerization : ISO:MGI
- regulation of activin receptor signaling pathway : ISO:MGI
- regulation of amyloid precursor protein catabolic process : ISO:MGI
- regulation of immune response : ISO:MGI
- regulation of protein localization : ISO:MGI
- regulation of ryanodine-sensitive calcium-release channel activity : IMP:BHF-UCL
- release of sequestered calcium ion into cytosol : IDA:MGI
- response to caffeine : IMP:MGI
- response to iron ion : IEA:Ensembl
- SMAD protein complex assembly : ISO:MGI
- supramolecular fiber organization : ISO:MGI
- T cell proliferation : IMP:MGI
- ventricular cardiac muscle tissue morphogenesis : IMP:BHF-UCL
|