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P26443

Glutamate dehydrogenase 1, mitochondrial (P26443)

Uniprot ID P26443
Protein Name Glutamate dehydrogenase 1, mitochondrial
Gene Name Glud1
Species Mus musculus (Mouse)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.483
Function Mitochondrial glutamate dehydrogenase that converts L-glutamate into alpha-ketoglutarate. Plays a key role in glutamine anaplerosis by producing alpha-ketoglutarate, an important intermediate in the tricarboxylic acid cycle. May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate. .
GO - Molecular function
  • ADP binding : ISO:MGI
  • ATP binding : IEA:UniProtKB-KW
  • enzyme binding : ISO:MGI
  • glutamate dehydrogenase (NAD+) activity : ISO:MGI
  • glutamate dehydrogenase [NAD(P)+] activity : IDA:UniProtKB
  • GTP binding : ISO:MGI
  • leucine binding : ISO:MGI
  • NAD+ binding : ISO:MGI
GO - Biological process
  • cerebellum development : IEA:Ensembl
  • glutamate biosynthetic process : ISO:MGI
  • glutamate catabolic process : ISO:MGI
  • glutamine metabolic process : IMP:UniProtKB
  • long-term memory : IEA:Ensembl
  • positive regulation of insulin secretion : IGI:MGI
  • response to aluminum ion : ISO:MGI
  • tricarboxylic acid metabolic process : IMP:UniProtKB
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.