CD44 antigen (P26051)

Uniprot ID	P26051
Protein Name	CD44 antigen
Gene Name	Cd44
Species	Rattus norvegicus (Rat)

Signal peptide^(a)	Y	Secretome P^(b)
Function	Cell-surface receptor that plays a role in cell-cell interactions, cell adhesion and migration, helping them to sense and respond to changes in the tissue microenvironment. Participates thereby in a wide variety of cellular functions including the activation, recirculation and homing of T-lymphocytes, hematopoiesis, inflammation and response to bacterial infection. Engages, through its ectodomain, extracellular matrix components such as hyaluronan/HA, collagen, growth factors, cytokines or proteases and serves as a platform for signal transduction by assembling, via its cytoplasmic domain, protein complexes containing receptor kinases and membrane proteases. Such effectors include PKN2, the RhoGTPases RAC1 and RHOA, Rho-kinases and phospholipase C that coordinate signaling pathways promoting calcium mobilization and actin-mediated cytoskeleton reorganization essential for cell migration and adhesion. .
GO - Molecular function	epidermal growth factor receptor binding : IPI:RGD hyaluronic acid binding : ISO:RGD phosphoprotein binding : IPI:RGD protein kinase binding : IPI:RGD transmembrane signaling receptor activity : IBA:GO_Central type II transforming growth factor beta receptor binding : ISO:RGD
GO - Biological process	blood vessel maturation : IEP:RGD branching involved in prostate gland morphogenesis : ISO:RGD branching involved in ureteric bud morphogenesis : ISO:RGD cartilage development : ISO:RGD cell adhesion : IMP:RGD cell migration : IMP:RGD cellular response to fibroblast growth factor stimulus : ISO:RGD cytokine-mediated signaling pathway : IEA:GOC hyaluronan catabolic process : ISO:RGD inflammatory response : IEP:RGD macrophage fusion : IMP:RGD monocyte aggregation : ISO:RGD negative regulation of apoptotic process : ISO:RGD negative regulation of CD4-positive, alpha-beta T cell proliferation : ISO:RGD negative regulation of cysteine-type endopeptidase activity involved in apoptotic process : ISO:RGD negative regulation of DNA damage response, signal transduction by p53 class mediator : ISO:RGD negative regulation of inflammatory response : ISO:RGD negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator : ISO:RGD negative regulation of mature B cell apoptotic process : ISO:RGD negative regulation of regulatory T cell differentiation : ISO:RGD neuron projection development : IMP:RGD positive regulation of ERK1 and ERK2 cascade : ISO:RGD positive regulation of gene expression : ISO:RGD positive regulation of heterotypic cell-cell adhesion : ISO:RGD positive regulation of kinase activity : ISO:RGD positive regulation of monocyte aggregation : ISO:RGD positive regulation of neutrophil apoptotic process : IMP:RGD positive regulation of peptidyl-serine phosphorylation : ISO:RGD positive regulation of peptidyl-tyrosine phosphorylation : ISO:RGD regulation of cell growth : IDA:RGD regulation of lamellipodium morphogenesis : ISS:UniProtKB response to organic cyclic compound : IEP:RGD response to vitamin A : IEP:RGD T cell activation : ISO:RGD Wnt signaling pathway : ISO:RGD wound healing involved in inflammatory response : ISO:RGD wound healing, spreading of cells : ISS:UniProtKB

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^{(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.}
^{(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.}