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P25391

Laminin subunit alpha-1 (P25391)

Uniprot ID P25391
Protein Name Laminin subunit alpha-1
Gene Name LAMA1
Species Homo sapiens (Human)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) Y Secretome P(b) 0.452
Function Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
GO - Molecular function
  • extracellular matrix structural constituent : ISS:UniProtKB
  • glycosphingolipid binding : IEA:Ensembl
  • protein C-terminus binding : IPI:CAFA
  • signaling receptor binding : IEA:InterPro
GO - Biological process
  • animal organ morphogenesis : IBA:GO_Central
  • axon guidance : IBA:GO_Central
  • blood vessel morphogenesis : IBA:GO_Central
  • branching involved in salivary gland morphogenesis : IEA:Ensembl
  • camera-type eye development : IBA:GO_Central
  • cell adhesion : IEA:UniProtKB-KW
  • cell surface receptor signaling pathway : ISS:UniProtKB
  • epithelial tube branching involved in lung morphogenesis : IEA:Ensembl
  • establishment of epithelial cell apical/basal polarity : IEA:Ensembl
  • extracellular matrix organization : TAS:Reactome
  • morphogenesis of an epithelial sheet : IEA:Ensembl
  • protein phosphorylation : IEA:Ensembl
  • regulation of cell adhesion : IEA:InterPro
  • regulation of cell migration : IEA:InterPro
  • regulation of embryonic development : IEA:InterPro
  • retinal blood vessel morphogenesis : IEA:Ensembl
  • tissue development : IBA:GO_Central
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.