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P25119

Tumor necrosis factor receptor superfamily member 1B (P25119)

Uniprot ID P25119
Protein Name Tumor necrosis factor receptor superfamily member 1B
Gene Name Tnfrsf1b
Species Mus musculus (Mouse)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) Y Secretome P(b) 0.271
Function Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2 (By similarity). .
GO - Molecular function
  • tumor necrosis factor-activated receptor activity : IPI:MGI
  • ubiquitin protein ligase binding : ISO:MGI
GO - Biological process
  • aging : IEA:Ensembl
  • cell proliferation : TAS:MGI
  • cell surface receptor signaling pathway : IMP:MGI
  • cellular response to growth factor stimulus : IEA:Ensembl
  • cellular response to lipopolysaccharide : ISO:MGI
  • extrinsic apoptotic signaling pathway : IMP:MGI
  • immune response : ISO:MGI
  • inflammatory response : IMP:MGI
  • intrinsic apoptotic signaling pathway in response to DNA damage : IMP:MGI
  • multicellular organism development : IBA:GO_Central
  • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process : IBA:GO_Central
  • negative regulation of inflammatory response : IMP:MGI
  • positive regulation of membrane protein ectodomain proteolysis : ISO:MGI
  • regulation of cell proliferation : IBA:GO_Central
  • response to lipopolysaccharide : IBA:GO_Central
  • RNA destabilization : IMP:MGI
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.