| Signal peptide(a) |
Y |
Secretome P(b) |
0.695 |
| Function |
Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis (By similarity). . |
| GO - Molecular function |
- identical protein binding : ISO:MGI
- protease binding : ISO:MGI
- protein-containing complex binding : ISO:MGI
- tumor necrosis factor binding : ISO:MGI
- tumor necrosis factor-activated receptor activity : IMP:MGI
|
| GO - Biological process |
- cell surface receptor signaling pathway : IMP:MGI
- cellular response to mechanical stimulus : IEA:Ensembl
- cytokine-mediated signaling pathway : IMP:MGI
- defense response : IMP:MGI
- defense response to bacterium : IMP:MGI
- immune response : IBA:GO_Central
- inflammatory response : IMP:MGI
- intrinsic apoptotic signaling pathway in response to DNA damage : IMP:MGI
- multicellular organism development : IBA:GO_Central
- negative regulation of apoptotic process : ISO:MGI
- negative regulation of gene expression : ISO:MGI
- negative regulation of inflammatory response : ISO:MGI
- negative regulation of interleukin-6 production : ISO:MGI
- positive regulation of angiogenesis : ISO:MGI
- positive regulation of gene expression : ISO:MGI
- positive regulation of I-kappaB kinase/NF-kappaB signaling : IEA:Ensembl
- positive regulation of inflammatory response : IMP:MGI
- positive regulation of neuron apoptotic process : ISO:MGI
- positive regulation of protein import into nucleus, translocation : ISO:MGI
- positive regulation of transcription by RNA polymerase II : IMP:MGI
- positive regulation of tumor necrosis factor production : ISO:MGI
- positive regulation of tyrosine phosphorylation of STAT protein : ISO:MGI
- prostaglandin metabolic process : TAS:MGI
- protein heterooligomerization : ISO:MGI
- protein localization to plasma membrane : ISO:MGI
- regulation of apoptotic process : ISO:MGI
- regulation of cell proliferation : IBA:GO_Central
- regulation of establishment of endothelial barrier : ISO:MGI
- response to lipopolysaccharide : IBA:GO_Central
- tumor necrosis factor-mediated signaling pathway : ISO:MGI
|