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P24821

Tenascin (P24821)

Uniprot ID P24821
Protein Name Tenascin
Gene Name TNC
Species Homo sapiens (Human)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.48
Function Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6. In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells (PubMed:19884327). .
GO - Molecular function
  • extracellular matrix structural constituent : ISS:BHF-UCL
  • syndecan binding : IDA:MGI
GO - Biological process
  • bud outgrowth involved in lung branching : IEA:Ensembl
  • cell adhesion : TAS:ProtInc
  • cellular protein metabolic process : TAS:Reactome
  • cellular response to prostaglandin D stimulus : IEA:Ensembl
  • cellular response to retinoic acid : IEA:Ensembl
  • cellular response to vitamin D : IEA:Ensembl
  • extracellular matrix organization : TAS:Reactome
  • mesenchymal-epithelial cell signaling involved in prostate gland development : IEA:Ensembl
  • negative regulation of cell adhesion : IEA:Ensembl
  • neuromuscular junction development : IEA:Ensembl
  • odontogenesis of dentin-containing tooth : IEA:Ensembl
  • osteoblast differentiation : HDA:UniProtKB
  • peripheral nervous system axon regeneration : IEA:Ensembl
  • positive regulation of cell population proliferation : IEA:Ensembl
  • positive regulation of gene expression : IEA:Ensembl
  • post-translational protein modification : TAS:Reactome
  • prostate gland epithelium morphogenesis : IEA:Ensembl
  • response to ethanol : IEA:Ensembl
  • response to fibroblast growth factor : IEA:Ensembl
  • response to mechanical stimulus : IEA:Ensembl
  • response to wounding : IEP:BHF-UCL
  • wound healing : IEA:Ensembl
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.